Chris E P Goldring
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Explore the profile of Chris E P Goldring including associated specialties, affiliations and a list of published articles.
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15
Citations
929
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Recent Articles
1.
Jorgensen A, Korver S, Schofield A, Howell L, Clarke J, Walker L, et al.
Br J Clin Pharmacol
. 2024 Dec;
PMID: 39676236
Aims: The potential of mechanistic biomarkers to improve prediction of drug-induced liver injury (DILI) and hepatic regeneration is widely acknowledged. We sought to determine reference intervals for new biomarkers of...
2.
Pridgeon C, Forootan S, Zhang F, Harper N, Palmer D, Weightmann R, et al.
J Stem Cells Regen Med
. 2023 Jun;
19(1):3-13.
PMID: 37366409
Human pluripotent stem cells (hPSCs) are a promising source of somatic cells for clinical applications and disease modelling. However, during culture they accumulate genetic aberrations such as amplification of 20q11.21...
3.
Ali S, Waddington J, Lister A, Sison-Young R, Jones R, Rehman A, et al.
Toxicol Sci
. 2023 Feb;
192(1):106-116.
PMID: 36782357
Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver injury. Although expression of HLA-B*57:01 is associated with increased susceptibility, little is known of the pathological mechanisms...
4.
Lynch S, Pridgeon C, Duckworth C, Sharma P, Park B, Goldring C
Biochem J
. 2019 Apr;
476(7):1149-1158.
PMID: 30988136
Adverse drug reactions (ADRs) are the unintended side effects of drugs. They are categorised as either predictable or unpredictable drug-induced injury and may be exhibited after a single or prolonged...
5.
Pridgeon C, Schlott C, Wong M, Heringa M, Heckel T, Leedale J, et al.
Arch Toxicol
. 2018 Jan;
92(2):557-569.
PMID: 29362863
The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a...
6.
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
Scarfe L, Brillant N, Kumar J, Ali N, Alrumayh A, Amali M, et al.
NPJ Regen Med
. 2018 Jan;
2:28.
PMID: 29302362
Regenerative medicine therapies hold enormous potential for a variety of currently incurable conditions with high unmet clinical need. Most progress in this field to date has been achieved with cell-based...
7.
Heslop J, Rowe C, Walsh J, Sison-Young R, Jenkins R, Kamalian L, et al.
Arch Toxicol
. 2016 Apr;
91(1):439-452.
PMID: 27039104
The application of primary human hepatocytes following isolation from human tissue is well accepted to be compromised by the process of dedifferentiation. This phenomenon reduces many unique hepatocyte functions, limiting...
8.
Heslop J, Hammond T, Santeramo I, Piella A, Hopp I, Zhou J, et al.
Stem Cells Transl Med
. 2015 Feb;
4(4):389-400.
PMID: 25722427
The field of stem cell therapeutics is moving ever closer to widespread application in the clinic. However, despite the undoubted potential held by these therapies, the balance between risk and...
9.
Kia R, Kelly L, Sison-Young R, Zhang F, Pridgeon C, Heslop J, et al.
Toxicol Sci
. 2014 Dec;
144(1):173-85.
PMID: 25527335
Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitulate the...
10.
Godoy P, Hewitt N, Albrecht U, Andersen M, Ansari N, Bhattacharya S, et al.
Arch Toxicol
. 2013 Aug;
87(8):1315-530.
PMID: 23974980
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the...