Chris C A Spencer
Overview
Explore the profile of Chris C A Spencer including associated specialties, affiliations and a list of published articles.
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45
Citations
9002
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Recent Articles
1.
Venkataraman G, DeBoever C, Tanigawa Y, Aguirre M, Ioannidis A, Mostafavi H, et al.
Am J Hum Genet
. 2021 Nov;
108(12):2354-2367.
PMID: 34822764
Whole-genome sequencing studies applied to large populations or biobanks with extensive phenotyping raise new analytic challenges. The need to consider many variants at a locus or group of genes simultaneously...
2.
Riveros-Mckay F, Weale M, Moore R, Selzam S, Krapohl E, Sivley R, et al.
Circ Genom Precis Med
. 2021 Mar;
14(2):e003304.
PMID: 33651632
Background: There is considerable interest in whether genetic data can be used to improve standard cardiovascular disease risk calculators, as the latter are routinely used in clinical practice to manage...
3.
Pedergnana V, Irving W, Barnes E, McLauchlan J, Spencer C
J Interferon Cytokine Res
. 2019 Jul;
39(10):642-649.
PMID: 31260374
Hepatitis C virus (HCV) genotype 3 is very prevalent in Europe and Asia and is associated with worst outcomes than other genotypes. Genetic factors have been associated with HCV infection;...
4.
Trochet H, Pirinen M, Band G, Jostins L, McVean G, Spencer C
Genet Epidemiol
. 2019 Mar;
43(5):532-547.
PMID: 30920090
Genome-wide association studies (GWAS) are a powerful tool for understanding the genetic basis of diseases and traits, but most studies have been conducted in isolation, with a focus on either...
5.
Diogo D, Tian C, Franklin C, Alanne-Kinnunen M, March M, Spencer C, et al.
Nat Commun
. 2018 Oct;
9(1):4285.
PMID: 30327483
Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying alternative indications, or predicting adverse drug events (ADEs). Here, we...
6.
Ramamurthy N, Marchi E, Ansari M, Pedergnana V, McLean A, Hudson E, et al.
Hepatology
. 2018 Mar;
68(3):859-871.
PMID: 29534310
New directly acting antivirals (DAAs) provide very high cure rates in most patients infected by hepatitis C virus (HCV). However, some patient groups have been relatively harder to treat, including...
7.
Gilchrist J, Rautanen A, Fairfax B, Mills T, Naranbhai V, Trochet H, et al.
Nat Commun
. 2018 Mar;
9(1):1014.
PMID: 29523850
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide...
8.
Klarin D, Zhu Q, Emdin C, Chaffin M, Horner S, McMillan B, et al.
Nat Genet
. 2017 Jul;
49(9):1392-1397.
PMID: 28714974
UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million...
9.
Leffler E, Band G, Busby G, Kivinen K, Le Q, Clarke G, et al.
Science
. 2017 May;
356(6343).
PMID: 28522690
The malaria parasite invades human red blood cells by a series of interactions between host and parasite surface proteins. By analyzing genome sequence data from human populations, including 1269 individuals...
10.
Ansari M, Pedergnana V, Ip C, Magri A, von Delft A, Bonsall D, et al.
Nat Genet
. 2017 Apr;
49(5):666-673.
PMID: 28394351
Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies...