Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease

Overview

Journal Nat Genet

Specialty Genetics

Date 2017 Jul 18

PMID 28714974

Citations 139

Authors

Derek Klarin

Qiuyu Martin Zhu

Connor A Emdin

Mark Chaffin

Steven Horner

Brian J McMillan

Alison Leed

Michael E Weale

Chris C A Spencer

Francois Aguet

Ayellet V Segre

Kristin G Ardlie

Amit V Khera

Virendar K Kaushik

Pradeep Natarajan

Sekar Kathiresan

Affiliations

Soon will be listed here.

Abstract

UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association with coronary artery disease (4,831 cases and 115,455 controls) and carried out meta-analysis with previously published results. We identified 15 new loci, bringing the total number of loci associated with coronary artery disease to 95 at the time of analysis. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

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