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Chiranjib Dasgupta

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Articles 44
Citations 1148
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Recent Articles
1.
Hu X, Song R, Dasgupta C, Liu T, Zhang M, Twum-Barimah S, et al.
J Physiol . 2024 Nov; 602(24):6729-6744. PMID: 39612361
The striking increase of uterine blood flow during pregnancy is essential for normal fetal development as well as for cardiovascular well-being of the mother. Yet, the underlying mechanisms of pregnancy-mediated...
2.
Kremsky I, Ma Q, Li B, Dasgupta C, Chen X, Ali S, et al.
Cell Biosci . 2023 Mar; 13(1):58. PMID: 36932456
Background: Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia...
3.
Hu X, Song R, Dasgupta C, Blood A, Zhang L
J Physiol . 2023 Mar; 601(8):1501-1514. PMID: 36856073
Hypoxia during pregnancy impairs uterine vascular adaptation via microRNA-210 (miR-210)-mediated mitochondrial dysfunction and mitochondrial reactive oxygen species (mtROS) generation. TET methylcytosine dioxygenase 2 (TET2) participates in regulating inflammation and oxidative...
4.
Hu X, Song R, Dasgupta C, Romero M, Juarez R, Hanson J, et al.
Br J Pharmacol . 2022 Jul; 179(19):4640-4654. PMID: 35776536
Background And Purpose: Hypoxia during pregnancy is associated with increased uterine vascular resistance and elevated blood pressure both in women and female sheep. A previous study demonstrated a causal role...
5.
Song R, Dasgupta C, Mulder C, Zhang L
Circulation . 2022 Mar; 145(15):1140-1153. PMID: 35296158
Background: Ischemic heart disease remains a leading cause of death worldwide. In this study, we test the hypothesis that microRNA-210 protects the heart from myocardial ischemia-reperfusion (IR) injury by controlling...
6.
Hu X, Dasgupta C, Song R, Romero M, Wilson S, Zhang L
Hypertension . 2021 Mar; 77(4):1412-1427. PMID: 33641365
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7.
Ma Q, Dasgupta C, Shen G, Li Y, Zhang L
J Neuroinflammation . 2021 Jan; 18(1):6. PMID: 33402183
Background: Neonatal hypoxic-ischemic (HI) brain injury is a leading cause of acute mortality and chronic disability in newborns. Our previous studies demonstrated that HI insult significantly increased microRNA-210 (miR-210) in...
8.
Hu X, Song R, Romero M, Dasgupta C, Min J, Hatcher D, et al.
Hypertension . 2020 Jul; 76(3):930-942. PMID: 32683903
Hypoxia during pregnancy profoundly affects uterine vascular adaptation and increases the risk of pregnancy complications, including preeclampsia and fetal intrauterine growth restriction. We recently demonstrated that increases in Ca sparks...
9.
Gao Y, Dasgupta C, Huang L, Song R, Zhang Z, Zhang L
Cells . 2019 Dec; 8(12). PMID: 31835778
Antenatal hypoxia caused epigenetic reprogramming of methylome and transcriptome in the developing heart and increased the risk of heart disease later in life. Herein, we investigated the impact of gestational...
10.
Li B, Dasgupta C, Huang L, Meng X, Zhang L
Cell Mol Immunol . 2019 Jul; 17(9):976-991. PMID: 31300734
Neuroinflammation is a major contributor to secondary neuronal injury that accounts for a significant proportion of final brain cell loss in neonatal hypoxic-ischemic encephalopathy (HIE). However, the immunological mechanisms that...