Chirag Acharya
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Explore the profile of Chirag Acharya including associated specialties, affiliations and a list of published articles.
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19
Citations
1156
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Recent Articles
1.
Nguyen B, Acharya C, Tangpanithandee S, Miao J, Krisanapan P, Thongprayoon C, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835388
Patients with IgA nephropathy (IgAN), including Henoch-Schönlein purpura nephritis (HSP), who present with rapidly progressive glomerulonephritis (RPGN) have a poor prognosis despite aggressive immunosuppressive therapy. The utility of plasmapheresis/plasma exchange...
2.
Thongprayoon C, Jadlowiec C, Leeaphorn N, Bruminhent J, Acharya P, Acharya C, et al.
Medicines (Basel)
. 2021 Nov;
8(11).
PMID: 34822363
: Black kidney transplant recipients have worse allograft outcomes compared to White recipients. The feature importance and feature interaction network analysis framework of machine learning random forest (RF) analysis may...
3.
Acharya P, Acharya C, Thongprayoon C, Hansrivijit P, Kanduri S, Kovvuru K, et al.
Diseases
. 2021 Jun;
9(2).
PMID: 34070285
Very-low-carbohydrate diets or ketogenic diets are frequently used for weight loss in adults and as a therapy for epilepsy in children. The incidence and characteristics of kidney stones in patients...
4.
Tai Y, Lin L, Xing L, Cho S, Yu T, Acharya C, et al.
Leukemia
. 2018 Aug;
33(2):426-438.
PMID: 30135465
We investigate here how APRIL impacts immune regulatory T cells and directly contributes to the immunosuppressive multiple myeloma (MM) bone marrow (BM) microenvironment. First, APRIL receptor TACI expression is significantly...
5.
Feng X, Zhang L, Acharya C, An G, Wen K, Qiu L, et al.
Clin Cancer Res
. 2017 Mar;
23(15):4290-4300.
PMID: 28249894
We study CD38 levels in immunosuppressive CD4CD25Foxp3 regulatory T cells (Treg) and further define immunomodulating effects of a therapeutic CD38 mAb isatuximab/SAR650984 in multiple myeloma. We evaluated percentages of CD38-expressing...
6.
Shi L, Qin X, Wang H, Xia Y, Li Y, Chen X, et al.
Oncotarget
. 2016 Nov;
8(12):18792-18801.
PMID: 27852046
Elevated inflammatory markers are associated with poor outcomes in various types of cancers; however, their clinical significance in multiple myeloma (MM) have seldom been explored. This study investigated the prognostic...
7.
Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication
An G, Acharya C, Feng X, Wen K, Zhong M, Zhang L, et al.
Blood
. 2016 Jul;
128(12):1590-603.
PMID: 27418644
The number and activity of osteoclasts (OCs) are strongly enhanced by myeloma cells, leading to significant bone lesions in patients with multiple myeloma (MM). Mechanisms remain elusive as to whether...
8.
Cea M, Cagnetta A, Acharya C, Acharya P, Tai Y, Yang C, et al.
Clin Cancer Res
. 2016 Jun;
22(24):6099-6109.
PMID: 27287071
Purpose: Nicotinamide phosphoribosyltransferase (Nampt) regulates intracellular NAD pool and is highly expressed in a number of malignancies. FK866, a selective inhibitor of Nampt, depletes intracellular NAD levels, thereby blocking cellular...
9.
Tai Y, Acharya C, An G, Moschetta M, Zhong M, Feng X, et al.
Blood
. 2016 Apr;
127(25):3225-36.
PMID: 27127303
Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) progression in vivo. BCMA downregulation strongly...
10.
Cea M, Cagnetta A, Adamia S, Acharya C, Tai Y, Fulciniti M, et al.
Blood
. 2015 Dec;
127(9):1138-50.
PMID: 26675349
Multiple myeloma (MM) is characterized by a highly unstable genome, with aneuploidy observed in nearly all patients. The mechanism causing this karyotypic instability is largely unknown, but recent observations have...