Chiou-Hong Lin
Overview
Explore the profile of Chiou-Hong Lin including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
828
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0
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Recent Articles
1.
Lin C, Vu J, Yang C, Sirisawad M, Chen C, Dao H, et al.
Am J Cancer Res
. 2021 Jul;
11(6):2911-2927.
PMID: 34249435
Acute myeloid leukemia (AML) is a highly heterogenous and aggressive disease with a poor prognosis, necessitating further improvements in treatment therapies. Recently, several targeted therapies have become available for specific...
2.
Lin C, Wang Z, Duque-Afonso J, Wong S, Demeter J, Loktev A, et al.
Sci Rep
. 2019 Mar;
9(1):4915.
PMID: 30894657
The PBX1 homeodomain transcription factor is converted by t(1;19) chromosomal translocations in acute leukemia into the chimeric E2A-PBX1 oncoprotein. Fusion with E2A confers potent transcriptional activation and constitutive nuclear localization,...
3.
Duque-Afonso J, Lin C, Han K, Morgens D, Jeng E, Weng Z, et al.
Cancer Res
. 2018 Sep;
78(22):6497-6508.
PMID: 30262461
Dasatinib is a multi-tyrosine kinase inhibitor approved for treatment of Ph acute lymphoblastic leukemia (ALL), but its efficacy is limited by resistance. Recent preclinical studies suggest that dasatinib may be...
4.
Lin C, Wong S, Kurzer J, Schneidawind C, Wei M, Duque-Afonso J, et al.
Cell Rep
. 2018 Apr;
23(4):1166-1177.
PMID: 29694893
Acute lymphoblastic leukemia (ALL) is associated with significant morbidity and mortality, necessitating further improvements in diagnosis and therapy. Targeted therapies directed against chromatin regulators are emerging as promising approaches in...
5.
Duque-Afonso J, Lin C, Han K, Wei M, Feng J, Kurzer J, et al.
Cancer Res
. 2016 Oct;
76(23):6937-6949.
PMID: 27758892
There is limited understanding of how signaling pathways are altered by oncogenic fusion transcription factors that drive leukemogenesis. To address this, we interrogated activated signaling pathways in a comparative analysis...
6.
Yang J, Feng X, Zhou Q, Cheng W, Shang C, Han P, et al.
Proc Natl Acad Sci U S A
. 2016 Sep;
113(38):E5628-35.
PMID: 27601681
Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of...
7.
Han P, Li W, Yang J, Shang C, Lin C, Cheng W, et al.
Biochim Biophys Acta
. 2016 Mar;
1863(7 Pt B):1772-81.
PMID: 26952936
Chromatin structure is determined by nucleosome positioning, histone modifications, and DNA methylation. How chromatin modifications are coordinately altered under pathological conditions remains elusive. Here we describe a stress-activated mechanism of...
8.
Buechele C, Breese E, Schneidawind D, Lin C, Jeong J, Duque-Afonso J, et al.
Blood
. 2015 Aug;
126(14):1683-94.
PMID: 26311362
Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and treatment-related leukemias and confer a poor prognosis. Studies based primarily on mouse models have substantially advanced our understanding...
9.
Duque-Afonso J, Feng J, Scherer F, Lin C, Wong S, Wang Z, et al.
J Clin Invest
. 2015 Aug;
125(9):3667-80.
PMID: 26301816
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer; however, its genetic diversity limits investigation into the molecular pathogenesis of disease and development of therapeutic strategies. Here, we engineered...
10.
Han P, Li W, Lin C, Yang J, Shang C, Nuernberg S, et al.
Nature
. 2014 Aug;
514(7520):102-106.
PMID: 25119045
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription, including...