Ching-ching Chua
Overview
Explore the profile of Ching-ching Chua including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
40
Followers
0
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Recent Articles
1.
Staben S, Feng J, Lyle K, Belvin M, Boggs J, Burch J, et al.
J Med Chem
. 2014 Jan;
57(3):1033-45.
PMID: 24432870
Structure-based methods were used to design a potent and highly selective group II p21-activated kinase (PAK) inhibitor with a novel binding mode, compound 17. Hydrophobic interactions within a lipophilic pocket...
2.
Ong Q, Lim M, Chua C, Cheung N, Wong B
Biochem Biophys Res Commun
. 2012 Jul;
424(3):482-7.
PMID: 22776200
Studies have shown similarities between the histopathological characteristics of NPC and Alzheimer's disease (AD) including amyloid and tau pathologies. While dysfunction in insulin signaling was widely detected in AD brain,...
3.
Chua C, Lim M, Wong B
J Neurochem
. 2010 Jan;
112(6):1619-26.
PMID: 20070866
Neurodegeneration is the final cause of death in Niemann-Pick Type C (NPC) disease, a cholesterol-storage disorder. Accumulating evidence indicates that NPC may share common pathological mechanisms with Alzheimer's disease, including...