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Boon-Seng Wong

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Articles 32
Citations 656
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Recent Articles
1.
Tan D, Boo B, Chong C, Tan M, Wong B
Front Aging Neurosci . 2022 Aug; 14:846271. PMID: 36034133
Introduction: Dementia is a neurodegenerative condition characterized by cognitive decline and increased functional dependency. With most persons living with dementia (PLWDs) residing at home, home-based interventions provide a convenient and...
2.
Gao Z, Shi J, Cai L, Luo M, Wong B, Dong X, et al.
Biochem Biophys Res Commun . 2019 Jan; 509(2):570-576. PMID: 30600179
The conversion of the normal prion protein (PrP) into a scrapie prion (PrP) is incompletely understood. Theoretically, the smallest PrP aggregate is a dimer. Human PrP contains two cysteines at...
3.
Chan E, Chen C, Soong T, Wong B
Neuromolecular Med . 2018 Feb; 20(1):124-132. PMID: 29450841
Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), where inheritance of this isoform predisposes development of AD in a gene dose-dependent manner. Although the...
4.
Zhu Y, Chai Y, Hilal S, Ikram M, Venketasubramanian N, Wong B, et al.
Alzheimers Dement (Amst) . 2017 Feb; 7:41-47. PMID: 28239640
Introduction: Neuroinflammation and cerebrovascular disease (CeVD) have been implicated in cognitive impairment and Alzheimer's disease (AD). The present study aimed to examine serum inflammatory markers in preclinical stages of dementia...
5.
Chan E, Shetty M, Sajikumar S, Chen C, Soong T, Wong B
Sci Rep . 2016 May; 6:26119. PMID: 27189808
The apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for Alzheimer's disease (AD). The AD brain was shown to be insulin resistant at end stage, but the interplay between...
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Chai Y, Yeo H, Wang J, Hilal S, Ikram M, Venketasubramanian N, et al.
J Alzheimers Dis . 2016 Mar; 51(4):1111-8. PMID: 26923016
Background And Objective: While the association for apolipoprotein ɛ4 allele (APOE4) with Alzheimer's disease (AD) has been consistently confirmed, the association with vascular cognitive impairment (VCI) is unclear. We therefore...
8.
Yang L, Gao Z, Hu L, Wu G, Yang X, Zhang L, et al.
J Biol Chem . 2015 Dec; 291(8):3905-17. PMID: 26683373
The normal cellular prion protein (PrP) is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. However, in pancreatic ductal adenocarcinoma cell lines, such as BxPC-3, PrP exists as a pro-PrP retaining its...
9.
Chan E, Chen C, Cole G, Wong B
Sci Rep . 2015 Sep; 5:13842. PMID: 26346625
It is unclear how human apolipoprotein E4 (ApoE4) increases the risk for Alzheimer's disease (AD). Although Aβ levels can lead to insulin signaling impairment, these experiments were done in the...
10.
Yong S, Lim M, Low C, Wong B
Sci Rep . 2014 Oct; 4:6580. PMID: 25301084
The effect of ApoE on NMDAR-dependent ERK/CREB signaling is isoform-dependent, and ApoE4 accelerates memory decline in ageing. However, this isoform-dependent function on neuronal signaling during ageing is unclear. In this...