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Ching-Cheng Hsu

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Articles 16
Citations 161
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Recent Articles
1.
Wang P, Ahmed M, Nguyen N, Menendez-Montes I, Hsu C, Farag A, et al.
J Clin Invest . 2025 Feb; 135(4). PMID: 39959972
Dilated cardiomyopathy (DCM) due to genetic disorders results in decreased myocardial contractility, leading to high morbidity and mortality rates. There are several therapeutic challenges in treating DCM, including poor understanding...
2.
Lam N, Nguyen N, Elhelaly W, Hsu C, Menendez-Montes I, Xiao F, et al.
Circulation . 2025 Feb; PMID: 39912233
Background: Cytokinesis is the last step in the eukaryotic cell cycle, which physically separates a mitotic cell into 2 daughter cells. A few days after birth in mouse cardiomyocytes, DNA...
3.
Wu Y, Chiao C, Chuang P, Hsieh C, Ko C, Ko C, et al.
Int J Med Sci . 2024 Sep; 21(12):2348-2364. PMID: 39310264
Recent advancements have elucidated the multifaceted roles of the Schlafen (SLFN) family, including SLFN5, SLFN11, SLFN12, SLFN13, and SLFN14, which are implicated in immunological responses. However, little is known about...
4.
Lam N, Nguyen N, Ahmed M, Hsu C, Rios Coronado P, Li S, et al.
Nat Cardiovasc Res . 2024 Aug; 1(7):679-688. PMID: 39196243
The mammalian neonatal heart can regenerate for 1 week after birth, after which, the majority of cardiomyocytes exit the cell cycle. Recent studies demonstrated that calcineurin mediates cell-cycle arrest of...
5.
Ahmed M, Nguyen N, Nakada Y, Hsu C, Farag A, Lam N, et al.
Nat Cardiovasc Res . 2024 Aug; 3(3):372-388. PMID: 39183959
Targeting Meis1 and Hoxb13 transcriptional activity could be a viable therapeutic strategy for heart regeneration. In this study, we performd an in silico screening to identify FDA-approved drugs that can...
6.
Chiang P, Cheng J, Chen D, Hsu C, Cruz Moreira R, Chou M
J Dent Sci . 2024 Jul; 19(3):1477-1485. PMID: 39035340
Background/purpose: Many patients pursue attractive smiles, and surgical-orthodontic treatment is a common method. We aimed to analyze the changes in smile parameters after surgical-orthodontic treatment in patients with skeletal Class...
7.
Nguyen N, Hsu C, Ali S, Wang H
Biochem Biophys Rep . 2024 Jul; 39:101762. PMID: 39026565
Background: Cell confluency and serum deprivation promote the transition of C2C12 myoblasts into myocytes and subsequence fusion into myotubes. However, despite all myoblasts undergoing the same serum deprivation trigger, their...
8.
Liu C, Ho Y, Lee W, Huang C, Lee Y, Hsieh C, et al.
Environ Toxicol . 2024 Jun; 39(11):4844-4858. PMID: 38884142
Environmental antineoplastics such as sorafenib may pose a risk to humans through water recycling, and the increased risk of cardiotoxicity is a clinical issue in sorafenib users. Thus, developing strategies...
9.
Xiao F, Nguyen N, Wang P, Li S, Hsu C, Thet S, et al.
Circulation . 2024 May; 150(10):791-805. PMID: 38708635
Background: Recent interest in understanding cardiomyocyte cell cycle has been driven by potential therapeutic applications in cardiomyopathy. However, despite recent advances, cardiomyocyte mitosis remains a poorly understood process. For example,...
10.
Ali S, Nguyen N, Menendez-Montes I, Hsu C, Elhelaly W, Lam N, et al.
J Cardiovasc Aging . 2024 Mar; 4(1). PMID: 38455514
Introduction: Gradual exposure to a chronic hypoxic environment leads to cardiomyocyte proliferation and improved cardiac function in mouse models through a reduction in oxidative DNA damage. However, the upstream transcriptional...