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Chin Yan Lim

Explore the profile of Chin Yan Lim including associated specialties, affiliations and a list of published articles. Areas
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Articles 25
Citations 792
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Recent Articles
1.
Tan C, Lim C, Lay K
Biology (Basel) . 2024 May; 13(5). PMID: 38785794
The hair follicle is a specialized appendage of the skin that is critical for multiple functions, including thermoregulation, immune surveillance, and sebum production. Mammals are born with a fixed number...
2.
Walters B, Tan T, Tan C, Dube C, Lee K, Koh J, et al.
J Cell Sci . 2023 Jun; 136(12). PMID: 37259855
The mammalian epidermis undergoes constant renewal, replenished by a pool of stem cells and terminal differentiation of their progeny. This is accompanied by changes in gene expression and morphology that...
3.
Sheppard S, Bryant L, Wickramasekara R, Vaccaro C, Robertson B, Hallgren J, et al.
Sci Adv . 2023 Mar; 9(10):eade1463. PMID: 36897941
Pathogenic variants in , a lysine methyltransferase, are associated with global developmental delay, macrocephaly, autism, and congenital anomalies (OMIM 617788). Given the relatively recent discovery of this disorder, it has...
4.
Tan C, Leo Z, Lim C
Biomed Mater . 2022 Oct; 17(6). PMID: 36268872
Skin is a complex organ made up of different cell layers, appendages, connective tissues, and immune repertoires. These different components interact extensively to maintain the overall functions of the integumentary...
5.
Dube C, Ong Y, Wemyss K, Krishnan S, Tan T, Janela B, et al.
Front Immunol . 2022 Jul; 13:943159. PMID: 35874681
Ageing-related delays and dysregulated inflammation in wound healing are well-documented in both human and animal models. However, cellular and molecular changes underlying this impairment in healing progression are not fully...
6.
Hwang J, Seo Y, Jeong D, Ning X, Wiraja C, Yang L, et al.
Adv Sci (Weinh) . 2022 Apr; 9(18):e2104835. PMID: 35460189
An effective wound management strategy needs accurate assessment of wound status throughout the whole healing process. This can be achieved by examining molecular biomarkers including proteins, DNAs, and RNAs. However,...
7.
Dube C, Jahan F, Lim C
Epigenetics . 2021 Apr; 17(4):444-459. PMID: 33890553
Dynamic shifts in chromatin states occur during embryonic epidermal development to support diverse epigenetic pathways that regulate skin formation and differentiation. However, it is not known whether the epigenomes established...
8.
Tan C, Liang K, Ngo Z, Dube C, Lim C
Biomedicines . 2020 Oct; 8(10). PMID: 33096771
Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15-25% of DM patients...
9.
Shue Y, Lee K, Walters B, Ong H, Silvaraju S, Lam W, et al.
Epigenetics . 2020 Mar; 15(9):932-948. PMID: 32175801
Post-translational modifications on nucleosomal histones represent a key epigenetic regulatory mechanism to mediate the complex gene expression, DNA replication, and cell cycle changes that occur in embryonic cells undergoing lineage...
10.
James C, Zhao T, Rahim A, Saxena P, Muthalif N, Uemura T, et al.
Stem Cells . 2018 Apr; 36(8):1170-1178. PMID: 29644784
Embryonic stem cells have the ability to self-renew or differentiate and these processes are under tight control. We previously reported that the polyamine regulator AMD1 is critical for embryonic stem...