Chiara Mastroleo
Overview
Explore the profile of Chiara Mastroleo including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
524
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0
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Recent Articles
1.
Pradella D, Zhang M, Gao R, Yao M, Gluchowska K, Cendon-Florez Y, et al.
Nature
. 2024 Dec;
637(8047):955-964.
PMID: 39695225
Focal gene amplifications are among the most common cancer-associated mutations but have proven challenging to engineer in primary cells and model organisms. Here we describe a general strategy to engineer...
2.
Pradella D, Zhang M, Gao R, Yao M, Gluchowska K, Florez Y, et al.
bioRxiv
. 2023 Jul;
PMID: 37425909
Focal gene amplifications are among the most common cancer-associated mutations, but their evolution and contribution to tumorigenesis have proven challenging to recapitulate in primary cells and model organisms. Here we...
3.
Strillacci A, Sansone P, Rajasekhar V, Turkekul M, Boyko V, Meng F, et al.
NPJ Breast Cancer
. 2022 Aug;
8(1):96.
PMID: 35999225
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone...
4.
La Rocca G, King B, Shui B, Li X, Zhang M, Akat K, et al.
Elife
. 2021 Aug;
10.
PMID: 34463618
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain...
5.
Li X, Pritykin Y, Concepcion C, Lu Y, La Rocca G, Zhang M, et al.
Mol Cell
. 2020 Jun;
79(1):167-179.e11.
PMID: 32497496
The identification of microRNA (miRNA) targets by Ago2 crosslinking-immunoprecipitation (CLIP) methods has provided major insights into the biology of this important class of non-coding RNAs. However, these methods are technically...
6.
Sansone P, Savini C, Kurelac I, Chang Q, Amato L, Strillacci A, et al.
Proc Natl Acad Sci U S A
. 2017 Oct;
114(43):E9066-E9075.
PMID: 29073103
The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit from dormancy have never been investigated. Here we identified the full mitochondrial genome in...
7.
Sansone P, Berishaj M, Rajasekhar V, Ceccarelli C, Chang Q, Strillacci A, et al.
Cancer Res
. 2017 Feb;
77(8):1927-1941.
PMID: 28202520
The hypothesis that microvesicle-mediated miRNA transfer converts noncancer stem cells into cancer stem cells (CSC) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis,...