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Chi Ho Ngan

Explore the profile of Chi Ho Ngan including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 231
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Recent Articles
1.
Lavi A, Ngan C, Movshovitz-Attias D, Bohnuud T, Yueh C, Beglov D, et al.
Proteins . 2013 Oct; 81(12):2096-105. PMID: 24123488
Peptide-mediated interactions, in which a short linear motif binds to a globular domain, play major roles in cellular regulation. An accurate structural model of this type of interaction is an...
2.
Bohnuud T, Beglov D, Ngan C, Zerbe B, Hall D, Brenke R, et al.
Nucleic Acids Res . 2012 Jun; 40(16):7644-52. PMID: 22705795
Formaldehyde has long been recognized as a hazardous environmental agent highly reactive with DNA. Recently, it has been realized that due to the activity of histone demethylation enzymes within the...
3.
Ngan C, Bohnuud T, Mottarella S, Beglov D, Villar E, Hall D, et al.
Nucleic Acids Res . 2012 May; 40(Web Server issue):W271-5. PMID: 22589414
Binding hot spots, protein sites with high-binding affinity, can be identified using X-ray crystallography or NMR by screening libraries of small organic molecules that tend to cluster at such regions....
4.
Hall D, Ngan C, Zerbe B, Kozakov D, Vajda S
J Chem Inf Model . 2011 Dec; 52(1):199-209. PMID: 22145575
Fragment-based drug design (FBDD) starts with finding fragment-sized compounds that are highly ligand efficient and can serve as a core moiety for developing high-affinity leads. Although the core-bound structure of...
5.
Hall D, Grove L, Yueh C, Ngan C, Kozakov D, Vajda S
J Am Chem Soc . 2011 Nov; 133(51):20668-71. PMID: 22092261
Binding hot spots, protein regions with high binding affinity, can be identified by using X-ray crystallography or NMR spectroscopy to screen libraries of small organic molecules that tend to cluster...
6.
Landon M, Amaro R, Baron R, Ngan C, Ozonoff D, McCammon J, et al.
Chem Biol Drug Des . 2008 Jan; 71(2):106-16. PMID: 18205727
The influenza virus subtype H5N1 has raised concerns of a possible human pandemic threat because of its high virulence and mutation rate. Although several approved anti-influenza drugs effectively target the...