Chi C Wong
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Explore the profile of Chi C Wong including associated specialties, affiliations and a list of published articles.
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29
Citations
678
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Recent Articles
1.
Simonin-Wilmer I, Ossio R, Leddin E, Harland M, Pooley K, Martil de la Garza M, et al.
J Med Genet
. 2022 Dec;
60(7):692-696.
PMID: 36539277
Pathogenic germline variants in the protection of telomeres 1 gene () have been associated with predisposition to a range of tumour types, including melanoma, glioma, leukaemia and cardiac angiosarcoma. We...
2.
Jaako P, Faille A, Tan S, Wong C, Escudero-Urquijo N, Castro-Hartmann P, et al.
Nat Commun
. 2022 Mar;
13(1):1562.
PMID: 35322020
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1-both mutated in the leukemia predisposition disorder Shwachman-Diamond syndrome -...
3.
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al.
Nat Commun
. 2021 May;
12(1):2482.
PMID: 33931647
While oncogenes promote tumorigenesis, they also induce deleterious cellular stresses, such as apoptosis, that cancer cells must combat by coopting adaptive responses. Whether tumor suppressor gene haploinsufficiency leads to such...
4.
De Franco E, Watson R, Weninger W, Wong C, Flanagan S, Caswell R, et al.
Am J Hum Genet
. 2019 Apr;
104(5):985-989.
PMID: 31006513
We report a recurrent CNOT1 de novo missense mutation, GenBank: NM_016284.4; c.1603C>T (p.Arg535Cys), resulting in a syndrome of pancreatic agenesis and abnormal forebrain development in three individuals and a similar...
5.
Wong K, Robles-Espinoza C, Rodriguez D, Rudat S, Puig S, Potrony M, et al.
JAMA Dermatol
. 2018 Dec;
155(5):604-609.
PMID: 30586141
Importance: The protection of telomeres 1 protein (POT1) is a critical component of the shelterin complex, a multiple-protein machine that regulates telomere length and protects telomere ends. Germline variants in...
6.
DeNicola G, Karreth F, Adams D, Wong C
Genome Biol
. 2015 Oct;
16:229.
PMID: 26481584
The use of transposons as insertional mutagens to identify cancer genes in mice has generated a wealth of information over the past decade. Here, we discuss recent major advances in...
7.
Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong C, et al.
Nat Struct Mol Biol
. 2015 Oct;
22(11):914-9.
PMID: 26479198
SBDS protein (deficient in the inherited leukemia-predisposition disorder Shwachman-Diamond syndrome) and the GTPase EFL1 (an EF-G homolog) activate nascent 60S ribosomal subunits for translation by catalyzing eviction of the antiassociation...
8.
Wong C, Cheng K, Papayannis I, Mattheolabakis G, Huang L, Xie G, et al.
Pharm Res
. 2014 Nov;
32(5):1663-75.
PMID: 25392229
Purpose: The purpose of the study was to evaluate the metabolism, pharmacokinetics and efficacy of phospho-NSAIDs in Ces1c-knockout mice. Methods: Hydrolysis of phospho-NSAIDs by Ces1c was investigated using Ces1c-overexpressing cells....
9.
Huang L, Wong C, Cheng K, Rigas B
PLoS One
. 2014 Nov;
9(11):e111720.
PMID: 25369051
Phospho-aspirin (PA-2) is a novel aspirin derivative that exhibits promising anticancer properties and is considerably safer than conventional aspirin. In this study, we investigated the chemotherapeutic efficacy of PA-2 in...
10.
Cheng K, Nie T, Ouyang N, Alston N, Wong C, Mattheolabakis G, et al.
Int J Pharm
. 2014 Oct;
477(1-2):236-43.
PMID: 25311177
Phospho-non-steroidal anti-inflammatory drugs (phospho-NSAIDs) are a novel class of NSAID derivatives with potent antitumor activity. However, phospho-NSAIDs have limited stability in vivo due to their rapid hydrolysis by carboxylesterases at...