Chi-Wing Kong
Overview
Explore the profile of Chi-Wing Kong including associated specialties, affiliations and a list of published articles.
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30
Citations
855
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Recent Articles
1.
Wong A, Wong N, Geng L, Chow M, Lee E, Wu H, et al.
Front Physiol
. 2020 Apr;
11:165.
PMID: 32226389
Although biomimetic stimuli, such as microgroove-induced alignment (μ), triiodothyronine (T3) induction, and electrical conditioning (EC), have been reported to promote maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), a systematic...
2.
Li S, Chopra A, Keung W, Chan C, Costa K, Kong C, et al.
Am J Physiol Heart Circ Physiol
. 2019 Jul;
317(5):H1105-H1115.
PMID: 31347915
Human pluripotent stem cell (hPSCs)-derived ventricular (V) cardiomyocytes (CMs) display immature Ca-handing properties with smaller transient amplitudes and slower kinetics due to such differences in crucial Ca-handling proteins as the...
3.
Chow M, Sadrian S, Keung W, Geng L, Ren L, Kong C, et al.
Sci Rep
. 2019 May;
9(1):7502.
PMID: 31097748
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have the ability of differentiating into functional cardiomyocytes (CMs) for cell replacement therapy, tissue engineering, drug discovery and toxicity...
4.
Geng L, Kong C, Wong A, Shum A, Chow M, Che H, et al.
Toxicol Lett
. 2018 May;
294:61-72.
PMID: 29758359
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are emerging tools for applications such as drug discovery and screening for pro-arrhythmogenicity and cardiotoxicity as leading causes for drug attrition. Understanding the electrophysiology...
5.
Ceholski D, Turnbull I, Kong C, Koplev S, Mayourian J, Gorski P, et al.
J Mol Cell Cardiol
. 2018 May;
119:147-154.
PMID: 29752948
Dilated cardiomyopathy (DCM) can be caused by mutations in the cardiac protein phospholamban (PLN). We used CRISPR/Cas9 to insert the R9C PLN mutation at its endogenous locus into a human...
6.
Kong C, Geng L, Li R
Methods Mol Biol
. 2017 Dec;
1722:185-194.
PMID: 29264806
Considerable interest has been raised to develop human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) as a model for drug discovery and cardiotoxicity screening. High-content electrophysiological analysis of currents generated by transmembrane...
7.
Stillitano F, Hansen J, Kong C, Karakikes I, Funck-Brentano C, Geng L, et al.
Elife
. 2017 Jan;
6.
PMID: 28134617
A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some...
8.
Kong C, Chen S, Geng L, Shum A, Sun D, Li R
Stem Cell Res
. 2017 Jan;
19:76-81.
PMID: 28086122
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) provide an unlimited source of donor cells for potential cardiac regenerative therapies. However, hPSC-CMs are immature. For instance, hPSC-CMs are only 1/10 of the...
9.
Shum A, Che H, Wong A, Zhang C, Wu H, Chan C, et al.
Adv Mater
. 2016 Nov;
29(1).
PMID: 27805726
A novel cardiomimetic biohybrid material, termed as the human ventricular cardiac anisotropic sheet (hvCAS) is reported. Well-characterized human pluripotent stem-cell-derived ventricular cardiomyocytes are strategically aligned to reproduce key electrophysiological features...
10.
Keung W, Ren L, Li S, Wong A, Chopra A, Kong C, et al.
Sci Rep
. 2016 Sep;
6:34154.
PMID: 27677332
Human embryonic stem cells (hESCs) is a potential unlimited ex vivo source of ventricular (V) cardiomyocytes (CMs), but hESC-VCMs and their engineered tissues display immature traits. In adult VCMs, sarcolemmal...