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Chester E Chamberlain

Explore the profile of Chester E Chamberlain including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 281
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Recent Articles
1.
Chamberlain C, German M, Philipson L, Anderson M
Cold Spring Harb Perspect Med . 2024 Dec; PMID: 39694696
Rare monogenic forms of disease provide a unique opportunity to understand novel pathways in human biology. With the rapid advances in genomics and next-generation sequencing, we now have the tools...
2.
Grier A, McGill J, Lord S, Speake C, Greenbaum C, Chamberlain C, et al.
AACE Clin Case Rep . 2023 Jul; 9(4):101-103. PMID: 37520758
Background: Identifying cases of diabetes caused by single gene mutations between the more common type 1 diabetes (T1D) and type 2 diabetes (T2D) is a difficult but important task. We...
3.
Perry D, Shapiro M, Chamberlain S, Kusmartseva I, Chamala S, Balzano-Nogueira L, et al.
Sci Data . 2023 May; 10(1):323. PMID: 37237059
The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of...
4.
Rutsch N, Chamberlain C, Dixon W, Spector L, Letourneau-Freiberg L, Lwin W, et al.
Diabetes Care . 2021 Jun; 44(8):1816-1825. PMID: 34172489
Objective: Multiple genome-wide association studies have identified a strong genetic linkage between the locus and type 1 diabetes (T1D), but how this leads to disease remains obscure. Here, we characterized...
5.
Moore P, Cortez J, Chamberlain C, Alba D, Berger A, Quandt Z, et al.
J Clin Invest . 2019 Aug; 129(11):4676-4681. PMID: 31369399
While improvements in genetic analysis have greatly enhanced our understanding of the mechanisms behind pancreatitis, it continues to afflict many families for whom the hereditary factors remain unknown. Recent evaluation...
6.
Chamberlain C, German M, Yang K, Wang J, VanBrocklin H, Regan M, et al.
Mol Cancer Ther . 2018 Sep; 17(12):2702-2709. PMID: 30254185
Patients with pancreatic neuroendocrine tumors (PNET) commonly develop advanced disease and require systemic therapy. However, treatment options remain limited, in part, because experimental models that reliably emulate PNET disease are...
7.
Tang S, Shen C, Lin P, Peng S, Chien H, Chou Y, et al.
Diabetologia . 2017 Sep; 61(1):158-167. PMID: 28864913
Aims/hypothesis: It has been proposed that the neuro-insular network enables rapid, synchronised insulin secretion. However, to date, acquiring the pancreatic tissue map to study the neural network remains a challenging...
8.
Tang S, Baeyens L, Shen C, Peng S, Chien H, Scheel D, et al.
Diabetologia . 2017 Aug; 61(1):168-181. PMID: 28852792
Aims/hypothesis: Identification of a pancreatic neuro-insular network in mice suggests that a similar integration of islets and nerves may be present in the human pancreas. To characterise the neuro-insular network...
9.
Chamberlain C, Scheel D, McGlynn K, Kim H, Miyatsuka T, Wang J, et al.
J Clin Invest . 2014 Aug; 124(9):4093-101. PMID: 25133424
Endocrine cell proliferation fluctuates dramatically in response to signals that communicate hormone demand. The genetic alterations that override these controls in endocrine tumors often are not associated with oncogenes common...
10.
Chamberlain C, Jeong J, Guo C, Allen B, McMahon A
Development . 2008 Feb; 135(6):1097-106. PMID: 18272593
Sonic hedgehog (Shh) ligand secreted by the notochord induces distinct ventral cell identities in the adjacent neural tube by a concentration-dependent mechanism. To study this process, we genetically engineered mice...