Cheryl A Conover
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Explore the profile of Cheryl A Conover including associated specialties, affiliations and a list of published articles.
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108
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2639
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Recent Articles
1.
Conover C
Growth Horm IGF Res
. 2025 Feb;
80:101637.
PMID: 39904113
Cellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth...
2.
Conover C
Growth Horm IGF Res
. 2024 Oct;
79:101625.
PMID: 39419664
There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular...
3.
Conover C, Oxvig C
Endocr Rev
. 2024 Oct;
46(2):214-223.
PMID: 39418083
There is strong evidence that IGF signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand...
4.
Bale L, West S, Gades N, Baker D, Conover C
Exp Neurol
. 2024 Sep;
382:114976.
PMID: 39349117
Alzheimer's disease (AD) is a progressive neurodegenerative disease of age with no effective preventative or treatment approaches. Deeper understanding of the mechanisms underlying the accumulation of toxic β-amyloid oligopeptides and...
5.
Conover C, Bale L, Stan M
J Clin Endocrinol Metab
. 2024 May;
109(12):3119-3125.
PMID: 38752390
Context: Proptosis in thyroid eye disease (TED) can result in facial disfigurement and visual dysfunction. Treatment with insulin-like growth factor I receptor (IGF-IR) inhibitors has been shown to be effective...
6.
Conover C, Oxvig C
Endocr Rev
. 2023 Jun;
44(6):1012-1028.
PMID: 37267421
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a placental protein of unknown function, present at high concentrations in the circulation of pregnant women. In the...
7.
Oxvig C, Conover C
J Clin Endocrinol Metab
. 2023 Jan;
108(7):1624-1633.
PMID: 36718521
The pappalysin metalloproteinases, PAPP-A and PAPP-A2, have emerged as highly specific proteolytic enzymes involved in the regulation of insulin-like growth factor (IGF) signaling. The only known pappalysin substrates are a...
8.
Conover C, Bale L
Exp Gerontol
. 2022 Dec;
172:112070.
PMID: 36549546
Senescence is a cellular response to various stressors characterized by irreversible cell cycle arrest, resistance to apoptosis and expression of a senescence-associated secretory phenotype (SASP). Interestingly, studies where senescent cells...
9.
Frobert A, Brohus M, Roesen T, Kindberg J, Frobert O, Conover C, et al.
Am J Physiol Endocrinol Metab
. 2022 Jul;
323(3):E307-E318.
PMID: 35830688
Brown bears conserve muscle and bone mass during 6 mo of inactive hibernation. The molecular mechanisms underlying hibernation physiology may have translational relevance for human therapeutics. We hypothesize that protective...
10.
Jepsen M, Ostergaard J, Conover C, Wogensen L, Birn H, Krag S, et al.
Metabolism
. 2022 May;
132:155218.
PMID: 35588861
Background: Diabetic nephropathy (DN) is a serious complication of diabetes and a common cause of end stage renal failure. Insulin-like growth factor (IGF)-signaling has been implicated in DN, but is...