Cheng-Jian Xu
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Explore the profile of Cheng-Jian Xu including associated specialties, affiliations and a list of published articles.
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97
Citations
3681
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Recent Articles
1.
Li W, Zhang Z, Kumar S, Botey-Bataller J, Zoodsma M, Ehsani A, et al.
Nat Aging
. 2025 Mar;
PMID: 40044970
Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect immune function, their relationship with biological immune aging and health status remains unclear....
2.
Alaswad A, Cabau G, Crisan T, Zhou L, Zoodsma M, Botey-Bataller J, et al.
Ann Rheum Dis
. 2025 Mar;
PMID: 40023733
Objectives: Gout, prevalent inflammatory arthritis caused by urate crystal deposition, involves immune cell activation, yet the precise role of CD14 monocytes in initiating the inflammatory response is poorly understood. This...
3.
Impact of COVID-19, lockdowns and vaccination on immune responses in a HIV cohort in the Netherlands
Otten T, Jiang X, Gupta M, Vadaq N, Cleophas-Jacobs M, Dos Santos J, et al.
Front Immunol
. 2025 Jan;
15:1459593.
PMID: 39744634
Introduction: During the COVID-19 pandemic, major events with immune-modulating effects at population-level included COVID-19 infection, lockdowns, and mass vaccinations campaigns. As immune responses influence many immune-mediated diseases, population scale immunological...
4.
Urbanek-Quaing M, Chou Y, Gupta M, Steppich K, Bremer B, Schmaus H, et al.
Hepatology
. 2024 Dec;
PMID: 39700467
Background And Aims: Chronic HBV infection exhausts HBV-specific T cells, develops epigenetic imprints that impair immune responses, and limits the effectiveness of immune checkpoint inhibitor monotherapy, such as anti-programmed cell...
5.
Tiede A, Stockhoff L, Liu Z, Rieland H, Mauz J, Ohlendorf V, et al.
Clin Mol Hepatol
. 2024 Nov;
31(1):240-255.
PMID: 39568127
Background/aims: Systemic Inflammation (SI) is considered a key mechanism in disease progression and development of complications in decompensated liver cirrhosis. SI is mainly driven by portal hypertension and bacterial translocation....
6.
Kumar S, Zoodsma M, Nguyen N, Pedroso R, Trittel S, Riese P, et al.
Sci Adv
. 2024 Sep;
10(39):eadq7006.
PMID: 39331702
Vaccination-induced protection against influenza is greatly diminished and increasingly heterogeneous with age. We investigated longitudinally (up to five time points) a cohort of 234 vaccinated >65-year-old vaccinees with adjuvanted vaccine...
7.
Tiede A, Stockhoff L, Rieland H, Liu Z, Mauz J, Tergast T, et al.
Aliment Pharmacol Ther
. 2024 Aug;
60(8):1021-1032.
PMID: 39192553
Background And Aims: Non-selective beta-blockers (NSBB) are a well-established treatment in patients with clinically significant portal hypertension. However, their potential role after insertion of a transjugular intrahepatic portosystemic shunt (TIPS)...
8.
Liu Z, Crisan T, Qi C, Gupta M, Liu X, Moorlag S, et al.
Res Sq
. 2024 Aug;
PMID: 39108482
Background: Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the...
9.
Kilic G, Debisarun P, Alaswad A, Baltissen M, Lamers L, de Bree L, et al.
Vaccine
. 2024 Jul;
42(24):126109.
PMID: 38981740
The Bacille Calmette-Guerin (BCG) vaccine is a well-established inducer of innate immune memory (also termed trained immunity), causing increased cytokine production upon heterologous secondary stimulation. Innate immune responses are known...
10.
Botey-Bataller J, Vrijmoeth H, Ursinus J, Kullberg B, van den Wijngaard C, Ter Hofstede H, et al.
Nat Commun
. 2024 May;
15(1):3795.
PMID: 38714679
The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine...