Chenfei He
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Explore the profile of Chenfei He including associated specialties, affiliations and a list of published articles.
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19
Citations
273
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Recent Articles
1.
Xu K, Feng H, Zhang H, He C, Kang H, Yuan T, et al.
Nat Biomed Eng
. 2024 Jun;
9(1):93-108.
PMID: 38831042
The applicability of cytosine base editors is hindered by their dependence on sequence context and by off-target effects. Here, by using AlphaFold2 to predict the three-dimensional structure of 1,483 cytidine...
2.
Li D, Cao Y, Xie L, He C, Jiao D, Ma M, et al.
Curr Issues Mol Biol
. 2024 May;
46(5):4021-4034.
PMID: 38785516
The demand for high-precision CRISPR/Cas9 systems in biomedicine is experiencing a notable upsurge. The editing system fdCas9 employs a dual-sgRNA strategy to enhance editing accuracy. However, the application of fdCas9...
3.
He C, Hua G, Liu Y, Li S
Cell Mol Biol Lett
. 2024 May;
29(1):76.
PMID: 38762740
Background: The role of the scavenger receptor CD36 in cell metabolism and the immune response has been investigated mainly in macrophages, dendritic cells, and T cells. However, its involvement in...
4.
Xin Y, Feng H, He C, Lu H, Zuo E, Yan N
Int J Biol Macromol
. 2024 Apr;
268(Pt 2):131785.
PMID: 38679258
To expand the scope of genomic editing, a C-to-G transversion-based editor called CGBE has been developed for precise single-nucleotide genomic editing. However, limited editing efficiency and product purity have hindered...
5.
Estupinan H, Bouderlique T, He C, Berglof A, Cappelleri A, Frengen N, et al.
Blood Adv
. 2024 Mar;
8(8):1981-1990.
PMID: 38507738
Bruton's tyrosine kinase (BTK) is an enzyme needed for B-cell survival, and its inhibitors have become potent targeted medicines for the treatment of B-cell malignancies. The initial activation event of...
6.
Xie L, Feng H, Li Z, Li D, Yang X, Yuan T, et al.
Genome Biol
. 2024 Feb;
25(1):51.
PMID: 38378658
The FokI catalytic domain can be fused to various DNA binding architectures to improve the precision of genome editing tools. However, evaluation of off-target effects is essential for developing these...
7.
Yan N, Feng H, Sun Y, Xin Y, Zhang H, Lu H, et al.
Nat Commun
. 2023 Mar;
14(1):1784.
PMID: 36997536
Base editors have been reported to induce off-target mutations in cultured cells, mouse embryos and rice, but their long-term effects in vivo remain unknown. Here, we develop a Systematic evaluation...
8.
Gao Y, Liu R, He C, Basile J, Vesterlund M, Wahren-Herlenius M, et al.
Front Immunol
. 2021 Apr;
12:642173.
PMID: 33815395
The suppressor of cytokine signaling 3 (SOCS3) is a major regulator of immune responses and inflammation as it negatively regulates cytokine signaling. Here, the role of SOCS3 in thymic T...
9.
He C, Wang S, Zhou C, He M, Wang J, Ladds M, et al.
Autophagy
. 2021 Feb;
17(11):3577-3591.
PMID: 33535890
Scavenger receptors are pattern recognition receptors that recognize both foreign and self-ligands, and initiate different mechanisms of cellular activation, often as co-receptors. The function of scavenger receptor CD36 in the...
10.
Garimella M, He C, Chen G, Li Q, Huang X, Karlsson M
J Autoimmun
. 2020 Dec;
117:102582.
PMID: 33296829
In systemic autoimmune diseases such as systemic lupus erythematosus (SLE), B cell tolerance is lost and there is a production of autoantibodies that drive pathology. The specificities of these antibodies...