Chen Ai
Overview
Explore the profile of Chen Ai including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
184
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Recent Articles
1.
Zhang Y, Ai C, Huang F, Zhao J, Ling Y, Chen W, et al.
Photochem Photobiol Sci
. 2025 Mar;
24(2):293-306.
PMID: 40025354
β-Nicotinamide mononucleotide (NMN), as a precursor of long-lived protein co-factor nicotinamide adenine dinucleotide (NAD) in the human body, has demonstrated promising clinical value in treating photoaging and skin wounds. Previous...
2.
Gao W, Yuan L, Zhang Y, Huang F, Ai C, Lv T, et al.
Photochem Photobiol Sci
. 2024 Apr;
23(5):957-972.
PMID: 38613601
Stem cell paracrine has shown potential application in skin wound repair and photoaging treatment. Our previous study demonstrated that miR-1246-overexpressing Exosomes (OE-EXs) isolated from adipose-derived stem cells (ADSCs) showed superior...
3.
Liu Y, Zhangding Z, Liu X, Gan T, Ai C, Wu J, et al.
Science
. 2024 Mar;
383(6688):1215-1222.
PMID: 38484065
DNA replication is initiated at multiple loci to ensure timely duplication of eukaryotic genomes. Sister replication forks progress bidirectionally, and replication terminates when two convergent forks encounter one another. To...
4.
Wu J, Liu Y, Zhangding Z, Liu X, Ai C, Gan T, et al.
Nat Genet
. 2023 Jul;
55(8):1347-1358.
PMID: 37500731
Cohesin loss-of-function mutations are frequently observed in tumors, but the mechanism underlying its role in tumorigenesis is unclear. Here, we found that depletion of RAD21, a core subunit of cohesin,...
5.
Ai C, Sun X, Xiao S, Guo L, Shang M, Shi D, et al.
J Nanobiotechnology
. 2023 Jul;
21(1):214.
PMID: 37420266
Despite rapid advances in metabolic therapies over the past decade, their efficacy in melanoma has been modest, largely due to the interaction between cancer-associated fibroblasts (CAFs) and cancer cells to...
6.
Xiao S, Guo L, Ai C, Shang M, Shi D, Meng D, et al.
ACS Appl Mater Interfaces
. 2023 Feb;
PMID: 36757913
Multiple drug resistance (MDR) exists in divergent cancers including triple negative breast cancer (TNBC) and partly results in the resistance to many first-line anti-cancer agents, bringing a big challenge to...
7.
He H, Guo X, Yu J, Ai C, Shi S
Bioinformatics
. 2021 Dec;
38(6):1542-1549.
PMID: 34908103
Motivation: Efficiently identifying genes based on gene expression level have been studied to help to classify different cancer types and improve the prediction performance. Logistic regression model based on regularization...
8.
Liu M, Zhang W, Xin C, Yin J, Shang Y, Ai C, et al.
Nucleic Acids Res
. 2021 Aug;
49(15):8732-8742.
PMID: 34365511
CRISPR-Cas9 generates double-stranded DNA breaks (DSBs) to activate cellular DNA repair pathways for genome editing. The repair of DSBs leads to small insertions or deletions (indels) and other complex byproducts,...
9.
Zhang W, Yin J, Zhang-Ding Z, Xin C, Liu M, Wang Y, et al.
Nucleic Acids Res
. 2021 Jun;
49(15):8785-8795.
PMID: 34133740
A series of Cas9 variants have been developed to improve the editing fidelity or targeting range of CRISPR-Cas9. Here, we employ a high-throughput sequencing approach primer-extension-mediated sequencing to analyze the...
10.
Liu Y, Ai C, Gan T, Wu J, Jiang Y, Liu X, et al.
Genome Biol
. 2021 Jun;
22(1):176.
PMID: 34108027
Background: Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA...