Chen-Yu Chiang
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Explore the profile of Chen-Yu Chiang including associated specialties, affiliations and a list of published articles.
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26
Citations
347
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Recent Articles
1.
Chiang C, Ohashi M, Tang Y
J Am Chem Soc
. 2025 Mar;
147(10):8113-8117.
PMID: 40029812
Fungal enzymes containing domain of unknown function (DUF) 3328 have been implicated in the oxidative maturation of ribosomally synthesized and post-translationally modified peptides (RiPPs). We report here the functional characterization...
2.
Yeh K, Kuan Y, Wu S, Chiang C, Chen C, Chen W, et al.
Environ Toxicol
. 2025 Feb;
PMID: 40013603
This research aimed to assess the potential of irigenin to attenuate blue light (BL)-induced apoptosis in human adult retinal pigment epithelial (hARPE-19) cells loaded with N-retinylidene-N-retinylethanolamine (A2E, DA50062). Furthermore, the...
3.
Chiang C, Ohashi M, Le J, Chen P, Zhou Q, Qu S, et al.
Nature
. 2025 Jan;
638(8049):126-132.
PMID: 39880944
Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp)-H...
4.
Yeh K, Wu S, Chiang C, Chen C, Chen W, Tseng C, et al.
Biomed Pharmacother
. 2024 Sep;
179:117346.
PMID: 39232385
Oxidative damage contributes to age-related macular degeneration. Irigenin possesses diverse pharmacologic properties, including antioxidative and antiapoptotic effects. Our in vivo experiments indicated that irigenin mitigates UVB-induced histopathologic changes and oxidative...
5.
Lu Y, Chiang C, Chen S, Hsu Y, Chen W, Chen C, et al.
Environ Toxicol Pharmacol
. 2024 May;
108:104468.
PMID: 38759849
Chlorpyrifos, widely used for pest control, is known to have various harmful effects, although its toxic effects in macrophages and the mechanisms underlying its toxicity remain unclear. The present study...
6.
Lu Y, Chiang C, Hsu Y, Chen C, Chen W, Tseng C, et al.
Environ Toxicol
. 2024 Feb;
39(5):2970-2979.
PMID: 38314619
Cyclizine, an over-the-counter and prescription antihistamine, finds widespread application in the prevention and treatment of motion sickness, encompassing symptoms such as nausea, vomiting, dizziness, along with its effectiveness in managing...
7.
Tsai P, Chiang C, Wang T, Yeh K, Chen W, Chen C, et al.
Environ Toxicol
. 2024 Feb;
39(5):2927-2936.
PMID: 38303669
Macrophages play an important role in defending the body against invading pathogens. In the face of pathogens, macrophages become activated and release toxic materials that disrupt the pathogens. Macrophage overactivation...
8.
Wu H, Chiang C, Chen W, Chen C, Tseng C, Chang Y, et al.
Environ Toxicol
. 2023 Aug;
38(12):2819-2825.
PMID: 37551787
Cyclizine exhibits sedation and treatment of nausea, vomiting, and motion sickness due to antihistaminic and antimuscarinic effects. Cyclizine has the potential for abuse due to the hallucinogenic and euphoric effect....
9.
Niwa K, Ohashi M, Xie K, Chiang C, Jamieson C, Sato M, et al.
J Am Chem Soc
. 2023 Jun;
145(25):13520-13525.
PMID: 37310230
We report biosynthetic pathways that can synthesize and transform conjugated octaenes and nonaenes to complex natural products. The biosynthesis of (-)-PF1018 involves an enzyme PfB that can control the regio-,...
10.
Hong Y, Chiang C, Wang Y, Chen S
J Acoust Soc Am
. 2023 Apr;
153(4):2406.
PMID: 37092944
A data-driven approach to constructing a prosodic grammar of Mandarin read speech is proposed. Prosodic labeling is performed, first, on a large speech corpus with syntactic-tree parsing to add four-level...