Chen-Jun Guo
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Explore the profile of Chen-Jun Guo including associated specialties, affiliations and a list of published articles.
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16
Citations
215
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Recent Articles
1.
Fu Y, Guo C, Liu Z, Liu J
Exp Cell Res
. 2024 Sep;
442(2):114262.
PMID: 39303837
The cytoophidium is a novel type of membraneless organelle, first observed in the ovaries of Drosophila using fluorescence microscopy. In vitro, purified Drosophila melanogaster CTPS (dmCTPS) can form metabolic filaments...
2.
Guo C, Zhang Z, Lu J, Zhong J, Wu Y, Guo S, et al.
J Mol Biol
. 2024 Aug;
436(20):168750.
PMID: 39173734
The final step in the de novo synthesis of cytidine 5'-triphosphate (CTP) is catalyzed by CTP synthase (CTPS), which can form cytoophidia in all three domains of life. Recently, we...
3.
Guo C, Zhang T, Leng Q, Zhou X, Zhong J, Liu J
Nat Plants
. 2024 May;
10(6):880-889.
PMID: 38740943
In plants, the rapid accumulation of proline is a common response to combat abiotic stress. Delta-1-pyrroline-5-carboxylate synthase (P5CS) is a rate-limiting enzyme in proline synthesis, catalysing the initial two-step conversion...
4.
5.
Guo C, Liu J
Biochem Soc Trans
. 2023 May;
51(3):1245-1256.
PMID: 37248970
The nucleotide CTP can be synthesized de novo from UTP via the metabolic enzyme CTP synthase (CTPS). As a textbook enzyme, CTPS has been extensively studied for seven decades. However,...
6.
Lu G, Hu H, Chang C, Zhong J, Zhou X, Guo C, et al.
Cell Biosci
. 2023 May;
13(1):100.
PMID: 37248548
Background: PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinucleotides and...
7.
Hu H, Lu G, Chang C, Li Y, Zhong J, Guo C, et al.
Elife
. 2022 Jun;
11.
PMID: 35736577
Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal regulation of PRPP synthase (PRPS) is associated...
8.
Bearne S, Guo C, Liu J
Biomolecules
. 2022 May;
12(5).
PMID: 35625575
Cytidine-5'-triphosphate (CTP) synthase (CTPS) is the class I glutamine-dependent amidotransferase (GAT) that catalyzes the last step in the de novo biosynthesis of CTP. Glutamine hydrolysis is catalyzed in the GAT...
9.
Zhong J, Guo C, Zhou X, Chang C, Yin B, Zhang T, et al.
Elife
. 2022 Mar;
11.
PMID: 35286254
The bifunctional enzyme Δ-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture. Pathogenic mutations in the P5CS gene...
10.
Zhou X, Guo C, Chang C, Zhong J, Hu H, Lu G, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34301892
Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis. The activity of CTPS is regulated...