Alpha 2.0
Login Register
» Authors » Chelsea Marie T Parrocha

Chelsea Marie T Parrocha

Explore the profile of Chelsea Marie T Parrocha including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 48
Followers 0
Related Specialties
Chemistry
Science
Top 10 Co-Authors
James S Nowick
Adam G Kreutzer
Gretchen Guaglianone
Michael A Morris
Jennifer T Nguyen
Maj Krumberger
Michelle N Diab
Ryan J Malonis
Karen Tong
Jonathan R Lai
Published In
Eur J Med Chem
Pept Sci (Hoboken)
ChemRxiv
Proc Natl Acad Sci U S A
ACS Cent Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Generation and Study of Antibodies against Two Triangular Trimers Derived from Aβ
Kreutzer A, Malonis R, Parrocha C, Tong K, Guaglianone G, Nguyen J, et al.
Pept Sci (Hoboken) . 2024 Apr; 116(2). PMID: 38644932
Monoclonal antibodies (mAbs) that target the P-amyloid peptide (Aβ) are important Alzheimer's disease research tools and are now being used as Alzheimer's disease therapies. Conformation-specific mAbs that target oligomeric and...
2.
Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue
Kreutzer A, Parrocha C, Haerianardakani S, Guaglianone G, Nguyen J, Diab M, et al.
ACS Cent Sci . 2024 Jan; 10(1):104-121. PMID: 38292607
Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are important tools in Alzheimer's disease research and have emerged as promising Alzheimer's disease therapies. This paper reports the...
3.
Probing differences among Aβ oligomers with two triangular trimers derived from Aβ
Kreutzer A, Guaglianone G, Yoo S, Parrocha C, Ruttenberg S, Malonis R, et al.
Proc Natl Acad Sci U S A . 2023 May; 120(22):e2219216120. PMID: 37216514
The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer's disease. Aβ is a shape-shifting peptide capable of...
4.
Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease
Parrocha C, Nowick J
Pept Sci (Hoboken) . 2023 Feb; 115(1). PMID: 36778914
Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) - the β-amyloid peptide (Aβ) and tau - are promising therapeutic avenues against...
5.
A cyclic peptide inhibitor of the SARS-CoV-2 main protease
Kreutzer A, Krumberger M, Diessner E, Parrocha C, Morris M, Guaglianone G, et al.
Eur J Med Chem . 2021 May; 221:113530. PMID: 34023738
This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (M). The cyclic peptide inhibitor is designed to mimic the conformation of...
6.
Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists
Zhang S, Krumberger M, Morris M, Parrocha C, Kreutzer A, Nowick J
Eur J Med Chem . 2021 Apr; 218:113390. PMID: 33812315
This paper describes the structure-based design of a preliminary drug candidate against COVID-19 using free software and publicly available X-ray crystallographic structures. The goal of this tutorial is to disseminate...
7.
Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientists
Zhang S, Krumberger M, Morris M, Parrocha C, Griffin J, Kreutzer A, et al.
ChemRxiv . 2020 Aug; PMID: 32817929
This paper describes the structure-based design of a preliminary drug candidate against COVID-19 using free software and publicly available X-ray crystallographic structures. The goal of this tutorial is to disseminate...