Che-Chang Chan
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Explore the profile of Che-Chang Chan including associated specialties, affiliations and a list of published articles.
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40
Citations
458
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Recent Articles
1.
Hsieh Y, Lee K, Lei H, Lan K, Huo T, Lin Y, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Jun;
12(3):813-838.
PMID: 34087453
Background & Aims: Activation of the (pro)renin receptor (PRR) up-regulates the expression of profibrotic genes in the kidney and heart. We aimed to investigate the role of PRR in hepatic...
2.
Lee K, Hsieh Y, Chan C, Sun H, Huang Y, Hou M, et al.
Lab Invest
. 2019 Mar;
99(8):1203-1216.
PMID: 30918325
Human relaxin-2 reduces hepatic fibrosis in mice. However, the effects of relaxin-2 on hepatic steatosis and fibrosis in animals with non-alcoholic fatty liver disease (NAFLD) remain to be elucidated. C57BL/6...
3.
Lee K, Hsu W, Hsieh Y, Chan C, Yang Y, Huang Y, et al.
Dig Dis Sci
. 2018 Oct;
64(1):102-112.
PMID: 30288660
Background: Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of...
4.
Lee K, Hsieh Y, Yang Y, Chan C, Huang Y, Lin H
Sci Rep
. 2016 Jan;
6:18899.
PMID: 26732252
Aliskiren has been found to reduce chronic injury and steatosis in the liver of methionine-choline-deficient (MCD) diet-fed mice. This study investigated whether aliskiren has an anti-steatotic effect in HFD-fed mice,...
5.
Chou C, Lee K, Chan C, Perng C, Chen C, Fang W, et al.
Medicine (Baltimore)
. 2015 Jul;
94(27):e1096.
PMID: 26166097
The optimal timing of percutaneous cholecystostomy for severe acute cholecystitis is unclear. The aim of this study was to investigate the timing of percutaneous cholecystostomy and its relationship to clinical...
6.
Yang Y, Hsieh S, Lee P, Yeh Y, Lee K, Hsieh Y, et al.
J Hepatol
. 2014 Jun;
61(5):1004-13.
PMID: 24953022
Background & Aims: Intestinal hyperpermeability, impaired peritoneal macrophages (PMs) phagocytosis, and bacterial translocation (BT), resulting in increased systemic and local infection/inflammation such as spontaneous bacterial peritonitis (SBP) together with increased...
7.
Lee K, Chan C, Yang Y, Hsieh Y, Huang Y, Lin H
PLoS One
. 2013 Nov;
8(10):e77817.
PMID: 24204981
Background & Aims: Activation of the renin-angiotensin-system is known to play a role in nonalcoholic steatohepatitis. Renin knockout mice manifest decreased hepatic steatosis. Aliskiren is the first direct renin inhibitor...
8.
Chan C, Lee K, Huang Y, Chou C, Lin H, Lee F
J Gastroenterol Hepatol
. 2013 Aug;
29(3):603-13.
PMID: 23981054
Background And Aim: Acute liver injury is manifested by different degree of hepatocyte necrosis and may recover via the process of hepatocyte regeneration once the injury is discontinued. Most of...
9.
Lee I, Lin C, Huang Y, Huo T, Su C, Hou M, et al.
PLoS One
. 2013 Mar;
8(2):e58071.
PMID: 23469142
Background Aims: The clinical relevance of single nucleotide polymorphisms (SNPs) near the IL28B gene is controversial in patients with hepatitis B virus (HBV) infection. This study aimed to investigate the...
10.
Chan C, Cheng L, Lu J, Huang Y, Chiou S, Tsai P, et al.
PLoS One
. 2012 Dec;
7(12):e50577.
PMID: 23227188
Background: Liver injuries are important medical problems that require effective therapy. Stem cell or hepatocyte transplantation has the potential to restore function of the damaged liver and ameliorate injury. However,...