Charles T Hanifin
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Explore the profile of Charles T Hanifin including associated specialties, affiliations and a list of published articles.
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20
Citations
331
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Recent Articles
1.
Geffeney S, Cordingley J, Mitchell K, Hanifin C
Mar Drugs
. 2022 Nov;
20(11).
PMID: 36422001
Multiple animal species have evolved resistance to the neurotoxin tetrodotoxin (TTX) through changes in voltage-gated sodium ion channels (VGSCs). Amino acid substitutions in TTX-resistant lineages appear to be positionally convergent...
2.
Hanifin C, Kudo Y, Yotsu-Yamashita M
Prog Chem Org Nat Prod
. 2022 Apr;
118:101-130.
PMID: 35416518
The North American newt genera Taricha and Notophthalmus (order Caudata) are well known for the combination of potent toxicity, aposematic coloration, and striking defense postures that protects these animals from...
3.
Reiskind M, Moody M, Bolnick D, Hanifin C, Farrior C
Bioscience
. 2021 Apr;
71(4):370-382.
PMID: 33867868
A key question in biology is the predictability of the evolutionary process. If we can correctly predict the outcome of evolution, we may be better equipped to anticipate and manage...
4.
Kudo Y, Hanifin C, Yotsu-Yamashita M
Org Lett
. 2021 Apr;
23(9):3513-3517.
PMID: 33830775
The biosynthesis of the potent neurotoxin tetrodotoxin (TTX, ) is still unresolved. We used MS-guided screening and nuclear magnetic resonance analyses including long-range HSQMBC to characterize two novel skeletal tricyclic...
5.
Kudo Y, Hanifin C, Kotaki Y, Yotsu-Yamashita M
J Nat Prod
. 2020 Sep;
83(9):2706-2717.
PMID: 32896120
The biosynthesis of tetrodotoxin (TTX, ), a potent neurotoxin widely distributed in marine and terrestrial metazoans, remains unresolved. A significant issue has been identifying intermediates and shunt products associated with...
6.
Geffeney S, Hanifin C
Methods Mol Biol
. 2019 Oct;
2068:283-290.
PMID: 31576535
Synthesizing and expressing ion channels in heterologous systems enable the characterization of the functional properties of these proteins. The cDNA that encodes ion channels can be amplified directly from mRNA...
7.
Geffeney S, Williams B, Rosenthal J, Birk M, Felkins J, Wisell C, et al.
Toxicon
. 2019 Sep;
170:77-84.
PMID: 31550451
The natural history and pharmacology of tetrodotoxin (TTX) has long intrigued biologists. This toxin has a remarkable distribution that spans two domains of life (Bacteria and Eukarya). Within Eukaryotes, TTX...
8.
Hague M, Toledo G, Geffeney S, Hanifin C, Brodie Jr E, Brodie 3rd E
Evol Lett
. 2018 Oct;
2(4):406-416.
PMID: 30283691
Adaptive evolution in response to one selective challenge may disrupt other important aspects of performance. Such evolutionary trade-offs are predicted to arise in the process of local adaptation, but it...
9.
McGlothlin J, Kobiela M, Feldman C, Castoe T, Geffeney S, Hanifin C, et al.
Curr Biol
. 2016 Jun;
26(12):1616-1621.
PMID: 27291053
Novel adaptations must originate and function within an already established genome [1]. As a result, the ability of a species to adapt to new environmental challenges is predicted to be...
10.
Hague M, Avila L, Hanifin C, Snedden W, Stokes A, Brodie Jr E, et al.
Ecol Evol
. 2016 Apr;
6(9):2714-24.
PMID: 27066249
Species interactions, and their fitness consequences, vary across the geographic range of a coevolutionary relationship. This spatial heterogeneity in reciprocal selection is predicted to generate a geographic mosaic of local...