Charles P Emerson Jr
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Explore the profile of Charles P Emerson Jr including associated specialties, affiliations and a list of published articles.
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40
Citations
1951
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Recent Articles
1.
Liu P, Ponnienselvan K, Nyalile T, Oikemus S, Joynt A, Iyer S, et al.
Nat Biotechnol
. 2024 Sep;
PMID: 39322763
In primary cell types, intracellular deoxynucleotide triphosphate (dNTP) levels are tightly regulated in a cell cycle-dependent manner. We report that prime editing efficiency is increased by mutations that improve the...
2.
Wong M, Hachmer S, Gardner E, Runfola V, Arezza E, Megeney L, et al.
Nucleic Acids Res
. 2024 Jul;
52(16):9450-9462.
PMID: 38994563
SMCHD1 is an epigenetic regulatory protein known to modulate the targeted repression of large chromatin domains. Diminished SMCHD1 function in muscle fibers causes Facioscapulohumeral Muscular Dystrophy (FSHD2) through derepression of...
3.
Cohen J, Huang S, Koczwara K, Woods K, Ho V, Woodman K, et al.
Cell Death Dis
. 2023 Nov;
14(11):749.
PMID: 37973788
Facioscapulohumeral muscular dystrophy (FSHD) is among the most common of the muscular dystrophies, affecting nearly 1 in 8000 individuals, and is a cause of profound disability. Genetically, FSHD is linked...
4.
Knox R, Eidahl J, Wallace L, Choudury S, Rashnonejad A, Daman K, et al.
Ann Neurol
. 2023 May;
94(2):398-413.
PMID: 37186119
Objective: Facioscapulohumeral muscular dystrophy (FSHD) is caused by abnormal de-repression of the myotoxic transcription factor DUX4. Although the transcriptional targets of DUX4 are known, the regulation of DUX4 protein and...
5.
Iyer S, Mir A, Vega-Badillo J, Roscoe B, Ibraheim R, Zhu L, et al.
CRISPR J
. 2022 Sep;
5(5):685-701.
PMID: 36070530
While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as...
6.
Ghasemi M, Emerson Jr C, Hayward L
Cells
. 2022 Feb;
11(4).
PMID: 35203336
Facioscapulohumeral muscular dystrophy (FSHD) is a debilitating muscular dystrophy with a variable age of onset, severity, and progression. While there is still no cure for this disease, progress towards FSHD...
7.
Guo D, Daman K, Chen J, Shi M, Yan J, Matijasevic Z, et al.
Elife
. 2022 Jan;
11.
PMID: 35076017
Skeletal muscle myoblasts (iMyoblasts) were generated from human induced pluripotent stem cells (iPSCs) using an efficient and reliable transgene-free induction and stem cell selection protocol. Immunofluorescence, flow cytometry, qPCR, digital...
8.
Brennan C, Emerson Jr C, Owens J, Christoforou N
JCI Insight
. 2021 Jun;
6(12).
PMID: 34156029
p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as...
9.
DeSimone A, Leszyk J, Wagner K, Emerson Jr C
Sci Adv
. 2019 Dec;
5(12):eaaw7099.
PMID: 31844661
Facioscapulohumeral muscular dystrophy (FSHD) is linked to epigenetic derepression of the germline/embryonic transcription factor DUX4 in skeletal muscle. However, the etiology of muscle pathology is not fully understood, as DUX4...
10.
Iyer S, Suresh S, Guo D, Daman K, Chen J, Liu P, et al.
Nature
. 2019 Apr;
568(7753):561-565.
PMID: 30944467
Current programmable nuclease-based methods (for example, CRISPR-Cas9) for the precise correction of a disease-causing genetic mutation harness the homology-directed repair pathway. However, this repair process requires the co-delivery of an...