Charles McSharry
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Explore the profile of Charles McSharry including associated specialties, affiliations and a list of published articles.
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50
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1725
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Recent Articles
1.
MacDonald L, Elmesmari A, Somma D, Frew J, Di Mario C, Madhu R, et al.
Immunity
. 2024 Nov;
57(12):2843-2862.e12.
PMID: 39609125
Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to reinstate tolerance in RA. Using single-cell...
2.
Ji Y, Wang E, Mohammed M, Hameed N, Christodoulou M, Liu X, et al.
Clin Immunol
. 2024 May;
264:110234.
PMID: 38740111
Background: Natural anti-cytokine autoantibodies can regulate homeostasis of infectious and inflammatory diseases. The anti-cytokine autoantibody profile and relevance to the pathogenesis of asthma are unknown. We aim to identify key...
3.
Komai-Koma M, Ji Y, Cao H, Liu Z, McSharry C, Xu D
Immunobiology
. 2021 Sep;
226(5):152132.
PMID: 34478947
Background: The monophosphoryl lipid A (MPLA) is a detoxified LPS derivative and an emerging safe immune adjuvant in human vaccine development. The adjuvant MPLA promotes antigen-presenting cell (APC) function and...
4.
Jackson M, Stevenson K, Chahal S, Curley E, Finney G, Gutierrez-Quintana R, et al.
Int J Radiat Oncol Biol Phys
. 2021 Sep;
112(1):197-211.
PMID: 34478832
Purpose: Low-dose whole lung radiation therapy (LDLR) has been proposed as a treatment for patients with acute respiratory distress syndrome associated with SARS-CoV-2 infection, and clinical trials are underway. There...
5.
MacDonald L, Alivernini S, Tolusso B, Elmesmari A, Somma D, Perniola S, et al.
JCI Insight
. 2021 Jun;
6(13).
PMID: 34143756
We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic and resolving macrophage pathways and their role in COVID-19 pathogenesis. We found that bronchoalveolar lavage fluid (BALF) macrophage...
6.
Barnes H, Olin A, Toren K, McSharry C, Donnelly I, Larstad M, et al.
ERJ Open Res
. 2020 Oct;
6(4).
PMID: 33043057
Background: Despite well-documented case series of hypersensitivity pneumonitis (HP), epidemiological data delineating relative contributions of risk factors are sparse. To address this, we estimated HP risk in a case-referent study...
7.
Ji Y, Bourke S, Spears M, Wain L, Boyd G, Lynch P, et al.
Clin Exp Allergy
. 2020 Sep;
50(12):1391-1399.
PMID: 32966647
Background: Identifying early stages of hypersensitivity pneumonitis (HP) is hampered by variable presentation, heterogeneous or undetected causal antigens and lack of gold-standard biomarkers. Krebs von den Lungen (KL)-6 is pathophysiological...
8.
Henderson I, Caiazzo E, McSharry C, Guzik T, Maffia P
Pharmacol Res
. 2020 Sep;
160:105189.
PMID: 32911071
Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma. They bind intracellular glucocorticoid receptors to trigger increased expression of anti-inflammatory genes and suppression of pro-inflammatory gene activation in...
9.
Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante M, et al.
Nat Med
. 2020 Jul;
26(8):1295-1306.
PMID: 32601335
Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics...
10.
Gurgone D, McShane L, McSharry C, Guzik T, Maffia P
Front Pharmacol
. 2020 Mar;
11:166.
PMID: 32194407
Cardiovascular disease (CVD) is an important comorbidity in a number of chronic inflammatory diseases. However, evidence in highly prevalent respiratory disease such as asthma are still limited. Epidemiological and clinical...