Charles H Rundle
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Explore the profile of Charles H Rundle including associated specialties, affiliations and a list of published articles.
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32
Citations
326
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Recent Articles
1.
Sheng M, Rundle C, Lau K
Cells
. 2025 Feb;
14(3).
PMID: 39936984
Extracellular vesicles (EVs), particularly exosomes (EXOs) of various skeletal and stem cells, were shown to delay osteoarthritis (OA) progression, and apoptotic bodies (ABs), another EV subtype, of osteoclasts showed osteoanabolic...
2.
Sheng M, Rundle C, Baylink D, Lau K
Calcif Tissue Int
. 2025 Jan;
116(1):28.
PMID: 39789342
This study assessed the novel concept that osteoclast-derived Grem1 has regulatory functions in the skeletal response to calcium stress using an osteoclastic Grem1 conditional knockout (cKO) mouse model. The calcium...
3.
Sheng M, Stiffel V, Taipia J, Rundle C, Lau K
Calcif Tissue Int
. 2025 Jan;
116(1):9.
PMID: 39751939
This study assessed the feasibility of miR17 ~ 92-based antiresorptive strategy by determining the effects of conditional transgenic (cTG) overexpression of miR17 ~ 92 in myeloid cells on bone and...
4.
Rundle C, Gomez G, Pourteymoor S, Mohan S
J Orthop Res
. 2022 Nov;
41(7):1471-1481.
PMID: 36448182
The increasing incidence of physiologic/pathologic conditions that impair the otherwise routine healing of endochondral bone fractures and the occurrence of severe bone injuries necessitate novel approaches to enhance clinically challenging...
5.
Gomez G, Rundle C, Xing W, Kesavan C, Pourteymoor S, Lewis R, et al.
Elife
. 2022 Nov;
11.
PMID: 36342465
Pathological obesity and its complications are associated with an increased propensity for bone fractures. Humans with certain genetic polymorphisms at the kinase suppressor of ras2 (KSR2) locus develop severe early-onset...
6.
Sheng M, Lau K, Rundle C, Alsunna A, Wilson S, Baylink D
J Bone Miner Metab
. 2022 Aug;
40(6):900-913.
PMID: 35947191
Introduction: This study was undertaken to gain mechanistic information about bone repair using the bone repletion model in aged Balb/cBy mice. Materials And Methods: one month-old (young) mice were fed...
7.
Stiffel V, Rundle C, Sheng M, Das S, Lau K
J Bone Miner Res
. 2022 Jan;
37(4):660-674.
PMID: 34989027
This study took advantage of the recent discovery that the EphA4 signaling has anti-catabolic effects on osteoclasts/macrophages/synoviocytes but pro-anabolic effects on articular chondrocytes and sought to develop an EphA4 signaling-based...
8.
Stiffel V, Thomas A, Rundle C, Sheng M, Lau K
Calcif Tissue Int
. 2020 Aug;
107(6):576-592.
PMID: 32816052
The expression and activation of EphA4 in the various cell types in a knee joint was upregulated upon an intraarticular injury. To determine if EphA4 signaling plays a role in...
9.
Kaur A, Mohan S, Rundle C
Animal Model Exp Med
. 2020 Jul;
3(2):130-139.
PMID: 32613172
Objective: To better characterize nonunion endochondral bone healing and evaluate novel therapeutic approaches for critical size defect healing in clinically challenging bone repair, a segmental defect model of bone injury...
10.
Chen W, Wasnik S, Fu Y, Aranda L, Rundle C, Lau K, et al.
Bone Rep
. 2019 Dec;
12:100236.
PMID: 31886323
In the present study we sought to improve the efficacy and safety of our Sca1 PDGFB stem cell gene therapy for osteoporosis in ovariectomized (OVX) mouse model. This therapy is...