Charles E Dann 3rd
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Explore the profile of Charles E Dann 3rd including associated specialties, affiliations and a list of published articles.
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32
Citations
1243
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Recent Articles
1.
Wallace-Povirk A, OConnor C, Dekhne A, Bao X, Nayeen M, Schneider M, et al.
Mol Cancer Ther
. 2024 Feb;
23(6):809-822.
PMID: 38377173
One-carbon (C1) metabolism is compartmentalized between the cytosol and mitochondria with the mitochondrial C1 pathway as the major source of glycine and C1 units for cellular biosynthesis. Expression of mitochondrial...
2.
Katinas J, Nayeen M, Schneider M, Shah K, Fifer A, Klapper L, et al.
Biochemistry
. 2024 Feb;
PMID: 38324671
We previously discovered first-in-class multitargeted 5-substituted pyrrolo[3,2-]pyrimidine antifolates that inhibit serine hydroxymethyltransferase 2 (SHMT2), resulting in potent in vitro and in vivo antitumor efficacies. In this report, we present crystallographic...
3.
Nayeen M, Katinas J, Magdum T, Shah K, Wong J, OConnor C, et al.
J Med Chem
. 2023 Aug;
66(16):11294-11323.
PMID: 37582241
Multitargeted agents provide tumor selectivity with reduced drug resistance and dose-limiting toxicities. We previously described the multitargeted 6-substituted pyrrolo[3,2-]pyrimidine antifolate with activity against early- and late-stage pancreatic tumors with limited...
4.
Tong N, Wong-Roushar J, Wallace-Povirk A, Shah Y, Nyman M, Katinas J, et al.
ACS Pharmacol Transl Sci
. 2023 May;
6(5):748-770.
PMID: 37200803
Multitargeted agents with tumor selectivity result in reduced drug resistance and dose-limiting toxicities. We report 6-substituted thieno[2,3-]pyrimidine compounds (-) with pyridine (, ), fluorine-substituted pyridine (), phenyl (, ), and...
5.
Hermanas T, Subramanian S, Dann 3rd C, Stewart G
J Bacteriol
. 2021 Jun;
203(17):e0013521.
PMID: 34096779
Bis-(3'-5')-cyclic-dimeric GMP (c-di-GMP) is an important bacterial regulatory signaling molecule affecting biofilm formation, toxin production, motility, and virulence. The genome of Bacillus anthracis, the causative agent of anthrax, is predicted...
6.
Wallace-Povirk A, Tong N, Wong-Roushar J, OConnor C, Zhou X, Hou Z, et al.
Bioorg Med Chem
. 2021 Mar;
37:116093.
PMID: 33773393
We discovered 6-substituted thieno[2,3-d]pyrimidine compounds (3-9) with 3-4 bridge carbons and side-chain thiophene or furan rings for dual targeting one-carbon (C1) metabolism in folate receptor- (FR) expressing cancers. Synthesis involved...
7.
Dekhne A, Shah K, Ducker G, Katinas J, Wong-Roushar J, Nayeen M, et al.
Mol Cancer Ther
. 2019 Jul;
18(10):1787-1799.
PMID: 31289137
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT) 2, provides...
8.
Hughes A, Subramanian S, Dann 3rd C, Kearns D
J Bacteriol
. 2018 Jan;
200(6).
PMID: 29311275
SwrA is the master activator of flagellar biosynthesis in , and SwrA activity is restricted by regulatory proteolysis in liquid environments. SwrA is proteolyzed by the LonA protease but requires...
9.
Subramanian S, Gao X, Dann 3rd C, Kearns D
Proc Natl Acad Sci U S A
. 2017 Dec;
114(51):13537-13542.
PMID: 29196522
Stator elements consisting of MotAMotB complexes are anchored to the cell wall, extend through the cell membrane, and interact with FliG in the cytoplasmic C ring rotor of the flagellum....
10.
Deis S, Doshi A, Hou Z, Matherly L, Gangjee A, Dann 3rd C
Biochemistry
. 2017 Feb;
56(7):1025.
PMID: 28186409
No abstract available.