Charles D Cox
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Explore the profile of Charles D Cox including associated specialties, affiliations and a list of published articles.
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55
Citations
1500
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Recent Articles
1.
Yu Z, Gong H, Kesteven S, Guo Y, Wu J, Li J, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(6):577-591.
PMID: 39195867
Pressure overload-induced cardiac hypertrophy is a maladaptive response with poor outcomes and limited treatment options. The transient receptor potential melastatin 4 (TRPM4) ion channel is key to activation of a...
2.
Wang H, Wang Y, Mirjavadi S, Andersen T, Moldovan L, Vatankhah P, et al.
Nat Commun
. 2024 Jul;
15(1):5521.
PMID: 38951553
The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors, yet the link between it and the ubiquitously expressed mechanosensitive ion channel PIEZO1 remains unclear. Herein, we describe a fluorescent...
3.
Janbandhu V, Tallapragada V, Li J, Shewale B, Ghazanfar S, Patrick R, et al.
Circulation
. 2024 Jun;
149(24):1931-1934.
PMID: 38857329
No abstract available.
4.
Cox C, Poole K, Martinac B
Trends Biochem Sci
. 2024 Jun;
49(8):693-702.
PMID: 38851904
Transient receptor potential (TRP) channels are implicated in a wide array of mechanotransduction processes. However, a question remains whether TRP channels directly sense mechanical force, thus acting as primary mechanotransducers....
5.
Han Y, Zhou Z, Jin R, Dai F, Ge Y, Ju X, et al.
Nature
. 2024 Apr;
628(8009):910-918.
PMID: 38570680
OSCA/TMEM63 channels are the largest known family of mechanosensitive channels, playing critical roles in plant and mammalian mechanotransduction. Here we determined 44 cryogenic electron microscopy structures of OSCA/TMEM63 channels in...
6.
Guo Y, Cheng D, Yu Z, Schiatti T, Chan A, Hill A, et al.
J Physiol
. 2023 Dec;
602(18):4363-4386.
PMID: 38098265
The transient receptor potential melastatin 4 (TRPM4) channel contributes extensively to cardiac electrical activity, especially cardiomyocyte action potential formation. Mechanical stretch can induce changes in heart rate and rhythm, and...
7.
Cheng D, Wang J, Yao M, Cox C
Biochem Soc Trans
. 2023 Sep;
51(5):1897-1906.
PMID: 37772664
Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as PIEZO1 are critical in mechanotransduction processes that influence cell differentiation, development, and cancer. Ample evidence now exists for regulatory...
8.
Zhou Z, Ma X, Lin Y, Cheng D, Bavi N, Secker G, et al.
Science
. 2023 Aug;
381(6659):799-804.
PMID: 37590348
Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel-binding proteins have...
9.
Zhang Y, Jiang F, Zhao Y, Cho A, Fang G, Cox C, et al.
Biomed Mater
. 2023 Jul;
18(5).
PMID: 37451254
During the final stage of cancer metastasis, tumor cells embed themselves in distant capillary beds, from where they extravasate and establish secondary tumors. Recent findings underscore the pivotal roles of...
10.
Zhang M, Shan Y, Cox C, Pei D
Nat Commun
. 2023 Jul;
14(1):3943.
PMID: 37402734
Mechanosensitive (MS) ion channels are a ubiquitous type of molecular force sensor sensing forces from the surrounding bilayer. The profound structural diversity in these channels suggests that the molecular mechanisms...