Charles B Trelford
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Explore the profile of Charles B Trelford including associated specialties, affiliations and a list of published articles.
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16
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1220
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Recent Articles
1.
Trelford C, Shepherd T
Genes Dis
. 2024 Dec;
12(2):101402.
PMID: 39735555
Genetic alterations to serine-threonine kinase 11 () have been implicated in Peutz-Jeghers syndrome and tumorigenesis. Further exploration of the context-specific roles of liver kinase B1 (LKB1; encoded by ) observed...
2.
Trelford C, Buensuceso A, Tomas E, Valdes Y, Hovey O, Li S, et al.
Cancers (Basel)
. 2024 Nov;
16(22).
PMID: 39594681
Late-stage epithelial ovarian cancer (EOC) involves the widespread dissemination of malignant disease throughout the peritoneal cavity, often accompanied by ascites. EOC metastasis relies on the formation of multicellular aggregates, called...
3.
4.
Trelford C, Shepherd T
Cell Commun Signal
. 2024 Jun;
22(1):310.
PMID: 38844908
Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 (STK11), is a master kinase that regulates cell migration, polarity, proliferation, and metabolism through downstream adenosine monophosphate-activated protein kinase (AMPK) and...
5.
Trelford C, Dagnino L, Di Guglielmo G
Front Mol Biosci
. 2022 Oct;
9:991612.
PMID: 36267157
Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function, and...
6.
Trelford C, Di Guglielmo G
Cell Signal
. 2022 Jul;
98:110414.
PMID: 35901932
Impairing autophagy disrupts transforming growth factor beta 1 (TGFβ1) signalling and epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Since autophagy and proteasome-mediated degradation are interdependent, we investigated how...
7.
Trelford C, Di Guglielmo G
Biochim Biophys Acta Mol Cell Res
. 2022 May;
1869(9):119284.
PMID: 35605790
Transforming growth factor beta (TGFβ) stimulates tumorigenesis by inducing epithelial to mesenchymal transition (EMT) and cell migration. TGFβ signaling is regulated by the endocytosis of cell surface receptors and their...
8.
Trelford C, Di Guglielmo G
Front Cell Dev Biol
. 2021 Nov;
9:712124.
PMID: 34760883
The mechanism(s) in which transforming growth factor beta 1 (TGFβ) modulates autophagy in cancer remain unclear. Here, we characterized the TGFβ signaling pathways that induce autophagy in non-small cell lung...
9.
Trelford C, Di Guglielmo G
Biochem J
. 2021 Sep;
478(18):3395-3421.
PMID: 34554214
The ubiquitin-proteasome pathway (UPP) and autophagy play integral roles in cellular homeostasis. As part of their normal life cycle, most proteins undergo ubiquitination for some form of redistribution, localization and/or...
10.
Trelford C, Ng E, Campbell C, Di Guglielmo G
Cell Signal
. 2021 May;
85:110040.
PMID: 34000385
Transforming growth factor beta (TGFβ) receptor trafficking regulates many TGFβ-dependent cellular outcomes including epithelial to mesenchymal transition (EMT). EMT in A549 non-small cell lung cancer (NSCLC) cells has recently been...