Charles Alende
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Explore the profile of Charles Alende including associated specialties, affiliations and a list of published articles.
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7
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Recent Articles
1.
Ayoubi R, Alende C, Fotouhi M, Ruiz Moleon V, Gonzalez Bolivar S, Southern K, et al.
F1000Res
. 2025 Mar;
13:1055.
PMID: 40028451
CSNK1A1 is a key regulator of various signalling pathways, including the Wnt/β-catenin pathway. Playing a central role in cellular function and disease pathology, CSNK1A1 has emerged as an attractive protein...
2.
Ruiz Moleon V, Alende C, Fotouhi M, Ayoubi R, Gonzalez Bolivar S, Laflamme C
F1000Res
. 2025 Feb;
13:1545.
PMID: 39949964
ADNP is a multifunctional protein involved in chromatin remodeling, transcription, and microtubule interaction, playing a critical role in brain development, with mutations linked to -Related Disorder. Here we have characterized...
3.
Ayoubi R, Fotouhi M, Alende C, Southern K, Laflamme C
F1000Res
. 2025 Feb;
13:1.
PMID: 39935523
Protein phosphatase 2A is a serine/threonine phosphatase with activity dependent on an associated regulatory subunit, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta (δ) isoform (PPP2R5D). PPP2R5D is the δ...
4.
Gonzalez Bolivar S, Ayoubi R, Alende C, Fothouhi M, Shlaifer I, McPherson P, et al.
F1000Res
. 2025 Feb;
13:1559.
PMID: 39916983
VAPB is an adaptor protein known for its role as an anchor for other proteins at the endoplasmic reticulum. A mutant form of VAPB has been linked to amyotrophic lateral...
5.
Ayoubi R, Ryan J, Gonzalez Bolivar S, Alende C, Ruiz Moleon V, Fotouhi M, et al.
Nat Protoc
. 2024 Dec;
PMID: 39690206
Antibody-based research applications are critical for biological discovery. Yet there are no industry standards for comparing the performance of antibodies in various applications. We describe a knockout cell line-based antibody...
6.
Ruiz Moleon V, Fotouhi M, Alende C, Ayoubi R, Bedford L, Southern K, et al.
F1000Res
. 2024 Oct;
13:77.
PMID: 39429638
Phosphatidylinositol-specific phospholipase C gamma 2 (PLC-gamma-2) is an enzyme that regulates the function of immune cells. PLC-gamma-2 has been implicated in neurodegenerative and autoimmune disorders, yet investigation of this protein...
7.
Ayoubi R, Fotouhi M, Alende C, Ruiz Moleon V, Southern K, Laflamme C
F1000Res
. 2024 Oct;
13:781.
PMID: 39403680
Casein kinase II subunit alpha (CSNK2A1), a serine/threonine kinase, phosphorylates multiple protein substrates and is involved in diverse cellular and biological processes. Implicated in various human diseases, high-performing antibodies would...
8.
Fanti R, Ayoubi R, Alende C, Fotouhi M, Gonzalez Bolivar S, Chandrasekaran R, et al.
F1000Res
. 2024 Sep;
13:922.
PMID: 39257448
Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative...
9.
Ayoubi R, Fotouhi M, Alende C, Gonzalez Bolivar S, Southern K, Laflamme C
F1000Res
. 2024 Sep;
13:481.
PMID: 39220380
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a Ca dependent enzyme that catalyzes transglutaminase cross-linking modifications. TGM2 is involved in various diseases, either in a protective or contributory manner, making it a...
10.
Biddle M, Alende C, Fotouhi M, Jones C, Ayoubi R, Southern K, et al.
F1000Res
. 2024 Aug;
13:817.
PMID: 39169954
Synaptotagmin-1 is a synaptic vesicle transmembrane protein that senses calcium influx via its tandem C2-domains, triggering synchronous neurotransmitter release. Disruption to is associated with neurodevelopmental disorders, highlighting the importance of...