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Changying Shi

Explore the profile of Changying Shi including associated specialties, affiliations and a list of published articles. Areas
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Articles 45
Citations 525
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Recent Articles
1.
Guo D, Shi C, Suo L, Ji X, Yue H, Yuan D, et al.
J Control Release . 2024 May; 370:626-642. PMID: 38734314
Severe nephrotoxicity and infusion-related side effects pose significant obstacles to the clinical application of Amphotericin B (AmB) in life-threatening systemic fungal infections. In pursuit of a cost-effective and safe formulation,...
2.
Yang X, Guo D, Ji X, Shi C, Messina J, Suo L, et al.
Acta Biomater . 2024 Mar; 178:147-159. PMID: 38447811
Wound infection commonly causes delayed healing, especially in the setting of chronic wounds. Local release of antibiotics is considered a viable approach to treat chronic wounds. We have developed a...
3.
Yang X, Guo D, Ji X, Shi C, Luo J
Macromol Rapid Commun . 2023 Aug; 44(23):e2300322. PMID: 37533180
Imbalanced immune regulation leads to the abnormal wound healing process, e.g., chronic unhealing wound or hypertrophic scar formation. Thus, the attenuation of the overflowing inflammatory factors is a viable approach...
4.
Ma J, Wang X, Gu R, Guo D, Shi C, Kollisch-Singule M, et al.
Shock . 2023 Mar; 59(6):922-929. PMID: 36939682
Background: The kidney is the most common extrapulmonary organ injured in sepsis. The current study examines the ability of aerosolized nanochemically modified tetracycline 3 (nCMT-3), a pleiotropic anti-inflammatory agent, to...
5.
Ji X, Shi C, Guo D, Yang X, Suo L, Luo J
Mol Pharm . 2023 Mar; 20(4):2138-2149. PMID: 36877183
Systemic fungal infections are an increasingly prevalent health problem. Amphotericin B (AmB), a hydrophobic polyene antibiotic, remains the drug of choice for life-threatening invasive fungal infections. However, it has dose-limiting...
6.
Ji X, Yang X, Shi C, Guo D, Wang X, Messina J, et al.
Adv Ther (Weinh) . 2023 Jan; 5(10). PMID: 36590645
Sepsis is a complex, life-threatening hyperinflammatory syndrome associated with organ failure and high mortality due to lack of effective treatment options. Here we report a core-shell hydrogel nanoparticle with the...
7.
Shi C, Li Y, Yang C, Qiao L, Tang L, Zheng Y, et al.
Front Immunol . 2022 Aug; 13:946861. PMID: 35967452
Background: Currently, no second-line systemic treatment regimen has been recommended in advanced biliary tract cancer (BTC). Cumulative clinical evidence showed that systemic treatment with tyrosine kinase inhibitors (TKIs) in combination...
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Wang X, Shi C, Zhang L, Lin M, Guo D, Wang L, et al.
ACS Macro Lett . 2022 Jun; 6(3):267-271. PMID: 35650900
Structure-based nanocarrier design for protein delivery remains challenging and has rarely been documented in the literature. We herein present a facile computer-aided approach for rational and customized design of a...
10.
Meng Q, Wang X, Guo D, Shi C, Gu R, Ma J, et al.
Shock . 2022 May; 57(5):749-758. PMID: 35583915
Background: Intratracheal (IT) lipopolysaccharide (LPS) causes severe acute lung injury (ALI) and systemic inflammation. CMT-3 has pleiotropic anti-inflammatory effects including matrix metalloproteinase (MMP) inhibition, attenuation of neutrophil (PMN) activation, and...