Chang-Yu Chen
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Explore the profile of Chang-Yu Chen including associated specialties, affiliations and a list of published articles.
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45
Citations
420
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Recent Articles
11.
Chen Y, You G, Lai M, Lu L, Chen C, Ting L, et al.
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33238517
Cisplatin is the first-line chemotherapy agent for head and neck cancer (HNC), but its therapeutic effects are hampered by its resistance. In this study, we employed systemic strategies to overcome...
12.
Lin Y, Wang J, Wu M, Lin Y, Chen C, Chen C, et al.
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32575412
Dysregulation of fatty acid oxidation and accumulation of fatty acids can cause kidney injury. Nifedipine modulates lipogenesis-related transcriptional factor SREBP-1/2 in proximal tubular cells by inhibiting the Adenosine 5'-monophosphate (AMP)-activated...
13.
Chen K, Chen C, Chen C, Tzou K, Peng C, Peng R
Int J Mol Sci
. 2020 May;
21(9).
PMID: 32403414
Combined androgen blockade using bicalutamide (Bic) is a therapeutic choice for treating prostate cancer (PCa). However, even at regular clinical dosages, Bic frequently shows adverse effects associated with cardiovascular and...
14.
Peng C, Chen C, Chen C, Lin Y, Chen K, Peng R
Int J Mol Sci
. 2020 May;
21(9).
PMID: 32365658
Nifedipine (NF) is reported to have many beneficial effects in antihypertensive therapy. Recently, we found that NF induced lipid accumulation in renal tubular cells. Palmitic acid-induced renal lipotoxicity was found...
15.
Lin Y, Wu M, Lin Y, Chen C, Chen C, Chen C, et al.
Int J Mol Sci
. 2019 Apr;
20(7).
PMID: 30934807
Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity in the kidney can be a surrogate marker for renal failure or renal...
16.
Peng C, Chen C, Chen C, Chen C, Shen K, Chen K, et al.
Sci Rep
. 2019 Mar;
9(1):3392.
PMID: 30833616
Bicalutamide (Bic) is frequently used in androgen deprivation therapy (ADT) for treating prostate cancer. ADT-induced hypogonadism was reported to have the potential to lead to acute kidney injury (AKI). ADT...
17.
Chen C, Wang Y, Lu C
Gastroenterology
. 2019 Mar;
157(1):e4-e5.
PMID: 30825487
No abstract available.
18.
Chen C, Ueha S, Ishiwata Y, Yokochi S, Yang D, Oppenheim J, et al.
J Immunother Cancer
. 2019 Jan;
7(1):21.
PMID: 30696484
Background: Transient depletion of CD4 T cells results in tumor suppression and survival benefit in murine models; however, the tumor progression and recurrence still occur over more long-term monitoring of...
19.
Chen C, Lin Y, Chen C, Chen Y
J Biomed Sci
. 2018 Mar;
25(1):30.
PMID: 29598816
Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rates of patients, poor...
20.
Tsai C, Chen C, Chiou Y, Shyu H, Lin K, Chou M, et al.
Int J Mol Sci
. 2017 Dec;
19(1).
PMID: 29267216
Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has been shown to induce cell death in cancer cells. Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpesvirus...