Chandramohan Wakade
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Explore the profile of Chandramohan Wakade including associated specialties, affiliations and a list of published articles.
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25
Citations
885
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Recent Articles
11.
Wakade C, Chong R
J Neurol Sci
. 2014 Dec;
347(1-2):34-8.
PMID: 25455298
We hypothesize that GPR109A message and expression are up-regulated in individuals with Parkinson's disease (PD). GPR109A is a high-affinity niacin receptor. Niacin is a precursor for NAD-NADH which is needed...
12.
Wakade C, Chong R, Bradley E, Thomas B, Morgan J
PLoS One
. 2014 Oct;
9(10):e109818.
PMID: 25329911
Background: Anecdotal animal and human studies have implicated the symptomatic and neuroprotective roles of niacin in Parkinson's disease (PD). Niacin has a high affinity for GPR109A, an anti-inflammatory receptor. Niacin...
13.
Wang J, Cheng A, Wakade C, Yu R
J Neurosci
. 2014 Oct;
34(41):13790-800.
PMID: 25297105
The maintenance of a neural stem cell (NSC) population in mammalian postnatal and adult life is crucial for continuous neurogenesis and neural repair. However, the molecular mechanism of how NSC...
14.
Khan M, Wakade C, de Sevilla L, Brann D
J Steroid Biochem Mol Biol
. 2014 May;
146:38-47.
PMID: 24815952
Selective estrogen receptor modulators (SERMs) have been reported to enhance synaptic plasticity and improve cognitive performance in adult rats. SERMs have also been shown to induce neuroprotection against cerebral ischemia...
15.
Ariga T, Wakade C, Yu R
Int J Alzheimers Dis
. 2011 Jan;
2011:193618.
PMID: 21274438
Conversion of the soluble, nontoxic amyloid β-protein (Aβ) into an aggregated, toxic form rich in β-sheets is a key step in the onset of Alzheimer's disease (AD). It has been...
16.
Ariga T, Yanagisawa M, Wakade C, Ando S, Buccafusco J, McDonald M, et al.
ASN Neuro
. 2010 Oct;
2(4):e00044.
PMID: 20930939
The accumulation of Aβ (amyloid β-protein) is one of the major pathological hallmarks in AD (Alzheimer's disease). Gangliosides, sialic acid-containing glycosphingolipids enriched in the nervous system and frequently used as...
17.
Wakade C, Sukumari-Ramesh S, Laird M, Dhandapani K, Vender J
J Neurosurg
. 2010 Apr;
113(6):1195-201.
PMID: 20397893
Object: Traumatic brain injury (TBI) induces significant neurological damage, including deficits in learning and memory, which contribute to a poor clinical prognosis. Treatment options to limit cognitive decline and promote...
18.
Wakade C, King M, Laird M, Alleyne Jr C, Dhandapani K
Antioxid Redox Signal
. 2008 Aug;
11(1):35-45.
PMID: 18752423
Cerebral vasospasm is a major cause of death and disability after subarachnoid hemorrhage (SAH); however, clinical therapies to limit the development of cerebral vasospasm are lacking. Although the causative factors...
19.
Laird M, Wakade C, Alleyne Jr C, Dhandapani K
Free Radic Biol Med
. 2008 Aug;
45(8):1103-14.
PMID: 18706498
Intracerebral hemorrhage (ICH) is a devastating neurological injury associated with significant mortality. Astrocytic inflammation may contribute to the pathogenesis of ICH, although the underlying cellular mechanisms remain unclear. In this...
20.
Wakade C, Khan M, De Sevilla L, Zhang Q, Mahesh V, Brann D
Endocrinology
. 2007 Sep;
149(1):367-79.
PMID: 17901229
The purpose of this study was to enhance our understanding of the mechanisms of neuronal death after focal cerebral ischemia and the neuroprotective effects of tamoxifen (TMX). The phosphorylation state...