Chandra C Ghosh
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Explore the profile of Chandra C Ghosh including associated specialties, affiliations and a list of published articles.
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35
Citations
1232
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Recent Articles
1.
Chan E, Ablooglu A, Ghosh C, Desai A, Schaible N, Chen X, et al.
Arterioscler Thromb Vasc Biol
. 2024 Oct;
44(12):2628-2646.
PMID: 39479769
Background: Vascular leakage is a deadly complication of severe infections, ranging from bacterial sepsis to malaria. Worldwide, septicemia is among the top 10 causes of lethality because of the shock...
2.
Ghosh C, Cournoyer L, Liu Y, Ballarin A, Layman I, LaPorte J, et al.
J Immunother Cancer
. 2024 Jul;
12(7).
PMID: 39038918
Background: Toll-like receptor 9 (TLR9) agonists induce inflammatory responses that promote the killing of infectious micro-organisms, cancer cells and develop adaptive immune responses. Their ability as immunomodulators to enhance the...
3.
Ghosh C, Heatherton K, Connell K, Alexander I, Greer D, LaPorte J, et al.
Cancer Gene Ther
. 2022 Jun;
29(12):1854-1865.
PMID: 35697801
Myeloid-derived suppressor cells (MDSCs) expand in response to malignancy and suppress responsiveness to immunotherapy, including checkpoint inhibitors (CPIs). Within the liver, MDSCs have unique immunosuppressive features. While TLR9 agonists have...
4.
Agur T, Wedel J, Bose S, Sahankumari A, Goodman D, Kong S, et al.
Am J Transplant
. 2021 Oct;
22(3):947-954.
PMID: 34687147
The statin family of therapeutics is widely used clinically as cholesterol lowering agents, and their effects to target intracellular mevalonate production is a key mechanism of action. In this study,...
5.
DaSilva N, Barlock B, Guha P, Ghosh C, Trebino C, Camberg J, et al.
Cell Death Discov
. 2021 Sep;
7(1):232.
PMID: 34482371
Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and diminishing the anti-tumor response of immunotherapies. While primary and metastatic tumors are...
6.
Chai L, Hardaway J, Heatherton K, OConnell K, Lopes M, Rabinowitz B, et al.
Vaccines (Basel)
. 2021 Aug;
9(8).
PMID: 34451932
Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the...
7.
Seyfoori A, Shokrollahi Barough M, Mokarram P, Ahmadi M, Mehrbod P, Sheidary A, et al.
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34203268
Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI). VRIs are proceeded by an infection caused by viruses infecting...
8.
Lu R, Zeki A, Ram-Mohan S, Nguyen N, Bai Y, Chmiel K, et al.
Front Pharmacol
. 2020 May;
11:469.
PMID: 32435188
Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening bronchoconstriction. To fill this therapeutic gap, we examined a potential...
9.
Redes J, Basu T, Ram-Mohan S, Ghosh C, Chan E, Sek A, et al.
Immunohorizons
. 2019 Oct;
3(8):368-377.
PMID: 31603851
The hallmark features of allergic asthma are type 2 (eosinophilic) inflammation and airways hyperresponsiveness (AHR). Although these features often comanifest in mouse lungs in vivo, we demonstrate in this study...
10.
Woda C, Bruneau S, Mak A, Haskova Z, Liu K, Ghosh C, et al.
Biochem Biophys Res Commun
. 2019 Sep;
519(4):667-673.
PMID: 31542230
Calcineurin Inhibitors (CNIs) are routinely used for immunosuppression following solid organ transplantation. However, the prolonged use of these agents lead to organ fibrosis which limits their efficacy. CNIs induce TGFβ...