Chad A Brautigam
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Explore the profile of Chad A Brautigam including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
4652
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Recent Articles
1.
Deka R, Tso S, Liu W, Brautigam C
PLoS One
. 2025 Jan;
20(1):e0312642.
PMID: 39787173
Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was...
2.
Ruiz N, Xing J, Zhulin I, Brautigam C, Hendrixson D
mBio
. 2024 Dec;
16(2):e0327824.
PMID: 39670710
Two-component signal transduction systems (TCSs) are nearly ubiquitous across bacterial species and enable bacteria to sense and respond to specific cues for environmental adaptation. The BumSR TCS is unusual in...
3.
Wu W, Kumar P, Brautigam C, Tso S, Baniasadi H, Kober D, et al.
Nat Commun
. 2024 Nov;
15(1):9653.
PMID: 39511182
The heme-based direct oxygen sensor DosP degrades c-di-GMP, a second messenger nearly unique to bacteria. In stationary phase Escherichia coli, DosP is the most abundant c-di-GMP phosphodiesterase. Ligation of O...
4.
Wu W, Kumar P, Brautigam C, Tso S, Baniasadi H, Kober D, et al.
bioRxiv
. 2024 Aug;
PMID: 39091779
The heme-based direct oxygen sensor DosP degrades c-di-GMP, a second messenger nearly unique to bacteria. In stationary phase , DosP is the most abundant c-di-GMP phosphodiesterase. Ligation of O to...
5.
Barylko B, Taylor 4th C, Wang J, Hedde P, Chen Y, Hur K, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928159
Arc (also known as Arg3.1) is an activity-dependent immediate early gene product enriched in neuronal dendrites. Arc plays essential roles in long-term potentiation, long-term depression, and synaptic scaling. Although its...
6.
Martin P, Kurth E, Budean D, Momplaisir N, Qu E, Simien J, et al.
PLoS One
. 2024 Apr;
19(4):e0298418.
PMID: 38625857
The chemokines of the immune system act as first responders by operating as chemoattractants, directing immune cells to specific locations of inflamed tissues. This promiscuous network is comprised of 50...
7.
Barylko B, Taylor 4th C, Wang J, Earnest S, Stippec S, Binns D, et al.
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38255853
Activity-regulated cytoskeleton-associated protein (Arc) plays essential roles in diverse forms of synaptic plasticity, including long-term potentiation (LTP), long-term depression (LTD), and homeostatic plasticity. In addition, it assembles into virus-like particles...
8.
Humphreys J, Teixeira L, Akella R, He H, Kannangara A, Sekulski K, et al.
Mol Biol Cell
. 2023 Aug;
34(11):ar109.
PMID: 37585288
Previous study has demonstrated that the WNK kinases 1 and 3 are direct osmosensors consistent with their established role in cell-volume control. WNK kinases may also be regulated by hydrostatic...
9.
Gonzalez A, Kim H, Freibaum B, Fung H, Brautigam C, Taylor J, et al.
Structure
. 2023 Jun;
31(8):924-934.e4.
PMID: 37279758
The HNRNPH2 proline-tyrosine nuclear localization signal (PY-NLS) is mutated in HNRNPH2-related X-linked neurodevelopmental disorder, causing the normally nuclear HNRNPH2 to accumulate in the cytoplasm. We solved the cryoelectron microscopy (cryo-EM)...
10.
Brautigam C, Deka R, Tso S, Liu W, Norgard M
PLoS One
. 2023 May;
18(5):e0283952.
PMID: 37200262
The mechanisms of energy generation and carbon-source utilization in the syphilis spirochete Treponema pallidum have remained enigmatic despite complete genomic sequence information. Whereas the bacterium harbors enzymes for glycolysis, the...