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Cesar Santiago

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Articles 35
Citations 1140
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Recent Articles
1.
Martinez-Martinez A, Gullace S, Resines-Urien E, Martin-Perez L, Collado J, Arranz R, et al.
Small . 2024 Dec; :e2408966. PMID: 39726330
Metal-Organic Frameworks (MOFs) attract attention for their intrinsic porosity, large surface area, and functional versatility. To fully utilize their potential in applications requiring precise control at smaller scales, it is...
2.
Martinez C, Iniesto E, Garcia-Leon M, Garcia-Corredera D, Fonseca S, Santiago C, et al.
Cell Rep . 2024 Oct; 43(10):114802. PMID: 39365702
Phytohormone abscisic acid (ABA) regulates key plant development and environmental stress responses. The ubiquitin-proteasome system tightly controls ABA signaling. CULLIN4-RING (CRL4) E3 ubiquitin ligases use the substrate receptor module CONSTITUTIVELY...
3.
Garcia-Cuesta E, Martinez P, Selvaraju K, Ulltjarn G, Gomez Pozo A, DAgostino G, et al.
Elife . 2024 Sep; 13. PMID: 39248648
CXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development. Despite...
4.
de Campos-Mata L, Trinite B, Modrego A, Tejedor Vaquero S, Pradenas E, Pons-Grifols A, et al.
Nat Commun . 2024 Feb; 15(1):1051. PMID: 38316751
Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a class 1...
5.
Velasco-Carneros L, Cuellar J, Dublang L, Santiago C, Marechal J, Martin-Benito J, et al.
Nat Commun . 2024 Jan; 15(1):99. PMID: 38167402
No abstract available.
6.
Velasco-Carneros L, Cuellar J, Dublang L, Santiago C, Marechal J, Martin-Benito J, et al.
Nat Commun . 2023 Sep; 14(1):5436. PMID: 37670029
J-domain proteins tune the specificity of Hsp70s, engaging them in precise functions. Despite their essential role, the structure and function of many J-domain proteins remain largely unknown. We explore human...
7.
Escos A, Martin-Gomez J, Gonzalez-Romero D, Diaz-Mora E, Francisco-Velilla R, Santiago C, et al.
Proc Natl Acad Sci U S A . 2022 Aug; 119(35):e2204752119. PMID: 35994673
p38γ and p38δ (p38γ/p38δ) regulate inflammation, in part by controlling tumor progression locus 2 (TPL2) expression in myeloid cells. Here, we demonstrate that TPL2 protein levels are dramatically reduced in...
8.
Bueno-Carrasco M, Cuellar J, Flydal M, Santiago C, Krakenes T, Kleppe R, et al.
Nat Commun . 2022 Jan; 13(1):74. PMID: 35013193
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Inhibition by catecholamines and reactivation...
9.
Barreda D, Santiago C, Rodriguez J, Rodriguez J, Casasnovas J, Merida I, et al.
Cells . 2021 Dec; 10(12). PMID: 34943787
Dendritic cells (DCs) are the most potent antigen-presenting cells, and their function is essential to configure adaptative immunity and avoid excessive inflammation. DCs are predicted to play a crucial role...
10.
Rojas J, Pascual E, Wattegedera S, Avia M, Santiago C, Martin V, et al.
Virulence . 2021 Feb; 12(1):690-703. PMID: 33522421
The toll-like receptor (TLR) family comprises both cell-surface and intracellular receptors that recognize different types of pathogen-associated molecular patterns (PAMPs) leading to the production of pro-inflammatory cytokines and subsequent development...