Cesar Meleza
Overview
Explore the profile of Cesar Meleza including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
63
Followers
0
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Recent Articles
1.
Mata G, Miles D, Drew S, Fournier J, Lawson K, Mailyan A, et al.
J Med Chem
. 2021 Oct;
65(2):1418-1444.
PMID: 34672584
Phosphoinositide-3-kinase γ (PI3Kγ) is highly expressed in immune cells and promotes the production and migration of inflammatory mediators. The inhibition of PI3Kγ has been shown to repolarize the tumor immune...
2.
Miles D, Yan X, Thomas-Tran R, Fournier J, Sharif E, Drew S, et al.
ACS Med Chem Lett
. 2020 Nov;
11(11):2244-2252.
PMID: 33214836
The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated...
3.
Drew S, Thomas-Tran R, Beatty J, Fournier J, Lawson K, Miles D, et al.
J Med Chem
. 2020 Sep;
63(19):11235-11257.
PMID: 32865410
The selective inhibition of the lipid signaling enzyme PI3Kγ constitutes an opportunity to mediate immunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due to the high...
4.
Robles O, Jackson J, Marshall L, Talay O, Chian D, Cutler G, et al.
J Med Chem
. 2020 Jul;
63(15):8584-8607.
PMID: 32667798
The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (T) as well as other circulating and tissue-resident T cells. T can be recruited to the tumor...
5.
Rescourio G, Gonzalez A, Jabri S, Belmontes B, Moody G, Whittington D, et al.
J Med Chem
. 2019 Nov;
62(22):10258-10271.
PMID: 31736296
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of...
6.
Jackson J, Ketcham J, Younai A, Abraham B, Biannic B, Beck H, et al.
J Med Chem
. 2019 Jul;
62(13):6190-6213.
PMID: 31259550
Recruitment of suppressive CD4 FOXP3 regulatory T cells (T) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents....
7.
Meleza C, Thomasson B, Ramachandran C, ONeill J, Michelsen K, Lo M
Anal Biochem
. 2016 Aug;
511:17-23.
PMID: 27485270
Prostaglandin D2 synthase (PGDS) catalyzes the isomerization of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 produced by hematopoietic prostaglandin D2 synthase (H-PGDS) in mast cells and Th2 cells is...
8.
Gustin D, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(8):2492-6.
PMID: 21392988
Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of...