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» Authors » Celine Schelcher

Celine Schelcher

Explore the profile of Celine Schelcher including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 729
Followers 0
Related Specialties
General Medicine
General Surgery
Biochemistry
Top 10 Co-Authors
Wolfgang E Thasler
Alison J Sinclair
Serene M L Lee
Elizabeth Verrall
Karl-Walter Jauch
Reinhard M K Thasler
Carlo Petosa
Anne Bellon
Jessie Wang
Questa H Karlsson
Published In
J Virol
PLoS One
Biochem Soc Trans
Langenbecks Arch Surg
J Surg Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Meta-analysis of Pharmacokinetic/Pharmacodynamic Results of 3 Phase 1 Studies with Biosimilar Pegfilgrastim
Gattu S, Wang J, Bellon A, Schelcher C, Nakov R, Arani R
Clin Pharmacol Drug Dev . 2021 Aug; 10(10):1130-1141. PMID: 34350732
A meta-analysis using data from 3 phase 1 studies evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of Sandoz biosimilar versus US- and EU-reference pegfilgrastim. The studies included a single-dose, double-blind,...
2.
A large multicentre, randomized, double-blind, cross-over study in healthy volunteers to compare pharmacokinetics, pharmacodynamics and safety of a pegfilgrastim biosimilar with its US- and EU-reference biologics
Bellon A, Wang J, Skerjanec A, Velinova M, Dickerson D, Sabet A, et al.
Br J Clin Pharmacol . 2020 Feb; 86(6):1139-1149. PMID: 32022282
Aims: Recombinant PEGylated human granulocyte colony-stimulating factor (pegfilgrastim) is indicated for the reduction of chemotherapy-induced neutropenia and prevention of febrile neutropenia. Biosimilar pegfilgrastim is expected to reduce the financial burden...
3.
Pre-Analytical Determination of the Effect of Extended Warm or Cold Ischaemia on RNA Stability in the Human Ileum Mucosa
Lee S, Schelcher C, Thasler R, Schiergens T, Thasler W
PLoS One . 2015 Sep; 10(9):e0138214. PMID: 26371767
The use of banked human tissue, obtained with informed consent after elective surgical procedures, represents a powerful model for understanding underlying mechanisms of diseases or therapeutic interventions and for establishing...
4.
An algorithm that predicts the viability and the yield of human hepatocytes isolated from remnant liver pieces obtained from liver resections
Lee S, Schelcher C, Laubender R, Frose N, Thasler R, Schiergens T, et al.
PLoS One . 2014 Oct; 9(10):e107567. PMID: 25313881
Isolated human primary hepatocytes are an essential in vitro model for basic and clinical research. For successful application as a model, isolated hepatocytes need to have a good viability and...
5.
Augmenter of liver regeneration attenuates inflammatory response in the postischemic mouse liver in vivo
Khandoga A, Mende K, Iskandarov E, Rosentreter D, Schelcher C, Reifart J, et al.
J Surg Res . 2014 Jun; 192(1):187-94. PMID: 24948544
Background: Augmenter of Liver Regeneration (ALR), a protein synthesized in the liver is suggested to be protective against oxidative stress-induced cell death. Hepatic ischemia-reperfusion (I/R) injury is triggered by reactive...
6.
Isolation of human hepatocytes by a two-step collagenase perfusion procedure
Lee S, Schelcher C, Demmel M, Hauner M, Thasler W
J Vis Exp . 2013 Sep; (79). PMID: 24056912
The liver, an organ with an exceptional regeneration capacity, carries out a wide range of functions, such as detoxification, metabolism and homeostasis. As such, hepatocytes are an important model for...
7.
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Godoy P, Hewitt N, Albrecht U, Andersen M, Ansari N, Bhattacharya S, et al.
Arch Toxicol . 2013 Aug; 87(8):1315-530. PMID: 23974980
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the...
8.
Biobanking for research in surgery: are surgeons in charge for advancing translational research or mere assistants in biomaterial and data preservation?
Thasler W, Thasler R, Schelcher C, Jauch K
Langenbecks Arch Surg . 2013 Feb; 398(4):487-99. PMID: 23430290
Background: High-quality biospecimens of human origin with annotated clinical and procedural data are an important tool for biomedical research, not only to map physiology, pathophysiology and aetiology but also to...
9.
RNA stability in human liver: comparison of different processing times, temperatures and methods
Lee S, Schelcher C, Gashi S, Schreiber S, Thasler R, Jauch K, et al.
Mol Biotechnol . 2012 Jan; 53(1):1-8. PMID: 22271457
The accuracy of information garnered by real-time quantitative polymerase chain reaction (RT-qPCR), an important technology for elucidating molecular mechanisms of disease, is dependent on tissue quality. Thus, this study aimed...
10.
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain
Mohamed T, Oceandy D, Zi M, Prehar S, Alatwi N, Wang Y, et al.
J Biol Chem . 2011 Oct; 286(48):41520-41529. PMID: 21965681
Identification of the signaling pathways that regulate cyclic nucleotide microdomains is essential to our understanding of cardiac physiology and pathophysiology. Although there is growing evidence that the plasma membrane Ca(2+)/calmodulin-dependent...