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Celestino Velasquez

Explore the profile of Celestino Velasquez including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 139
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Sun R, Cheng E, Velasquez C, Chang Y, Moore P
J Biol Chem . 2019 Jun; 294(31):11840-11852. PMID: 31201269
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E. Phosphorylation at Ser-83 of 4E-BP1 occurs during...
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Velasquez C, Amako Y, Harold A, Toptan T, Chang Y, Shuda M
Front Microbiol . 2018 Apr; 9:713. PMID: 29696010
Merkel cell polyomavirus (MCV) plays a causal role in ∼80% of Merkel cell carcinomas (MCC). MCV is clonally integrated into the MCC tumor genome, which results in persistent expression of...
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Velasquez C, Cheng E, Shuda M, Lee-Oesterreich P, Pogge von Strandmann L, Gritsenko M, et al.
Proc Natl Acad Sci U S A . 2016 Jul; 113(30):8466-71. PMID: 27402756
Mammalian target of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation promotes cap-dependent translation and tumorigenesis. During mitosis, cyclin-dependent kinase 1 (CDK1) substitutes for mTOR and fully...
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Shuda M, Velasquez C, Cheng E, Cordek D, Kwun H, Chang Y, et al.
Proc Natl Acad Sci U S A . 2015 Apr; 112(19):5875-82. PMID: 25883264
Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis revealed by a viral oncoprotein,...