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Celerino Abad-Zapatero

Explore the profile of Celerino Abad-Zapatero including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 103
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Recent Articles
1.
Abad-Zapatero C
Drug Discov Today . 2024 Apr; 29(5):103978. PMID: 38599277
No abstract available.
2.
Greco G, Segretti N, Abad-Zapatero C, Movahedzadeh F, Hirata M, Ferreira E, et al.
J Biomol Struct Dyn . 2023 Oct; 42(22):12408-12416. PMID: 37837432
Tuberculosis (TB) is a major global cause of mortality, primarily stemming from latent tuberculosis infection (LTBI). Failure to fully treat LTBI can result in drug-resistant forms of TB. Therefore, it...
3.
Selezneva A, Harding L, Gutka H, Movahedzadeh F, Abad-Zapatero C
PLoS One . 2023 Jun; 18(6):e0274723. PMID: 37352301
Class II Fructose-1,6-bisphosphatases (FBPaseII) (EC: 3.1.3.11) are highly conserved essential enzymes in the gluconeogenic pathway of microorganisms. Previous crystallographic studies of FBPasesII provided insights into various inactivated states of the...
4.
Abad-Zapatero C
Acta Crystallogr D Struct Biol . 2022 Feb; 78(Pt 2):260-267. PMID: 35102891
The suggestion is made that combining analysis using the most advanced crystallographic software with the integrated visual tools of the field will result in more knowledgeable and better trained future...
5.
Abad-Zapatero C
Acta Crystallogr D Struct Biol . 2021 May; 77(Pt 5):703-711. PMID: 33950024
The importance of the Fourier transform as a fundamental tool for crystallography is well known in the field. However, the complete legacy of Jean-Baptiste Joseph Fourier (1768-1830) as a pioneer...
6.
Abad-Zapatero C
Expert Opin Drug Discov . 2021 Feb; 16(7):763-775. PMID: 33522838
Introduction: The area of ligand efficiency indices (LEIs) in drug discovery has developed significantly since the initial publications nearly 20 years ago. A large number of different LEIs have been...
7.
Selezneva A, Gutka H, Wolf N, Qurratulain F, Movahedzadeh F, Abad-Zapatero C
Acta Crystallogr F Struct Biol Commun . 2020 Nov; 76(Pt 11):524-535. PMID: 33135671
The crystal structure of the class II fructose-1,6-bisphosphatase (FBPaseII) from the important pathogen Francisella tularensis is presented at 2.4 Å resolution. Its structural and functional relationships to the closely related...
8.
Wolf N, Lee H, Zagal D, Nam J, Oh D, Lee H, et al.
Acta Crystallogr D Struct Biol . 2020 May; 76(Pt 5):458-471. PMID: 32355042
The biological processes related to protein homeostasis in Mycobacterium tuberculosis, the etiologic agent of tuberculosis, have recently been established as critical pathways for therapeutic intervention. Proteins of particular interest are...
9.
Wolf N, Lee H, Choules M, Pauli G, Phansalkar R, Anderson J, et al.
ACS Infect Dis . 2019 Apr; 5(6):829-840. PMID: 30990022
Addressing the urgent need to develop novel drugs against drug-resistant Mycobacterium tuberculosis ( M. tb) strains, ecumicin (ECU) and rufomycin I (RUFI) are being explored as promising new leads targeting...
10.
Wolf N, Gutka H, Movahedzadeh F, Abad-Zapatero C
Acta Crystallogr D Struct Biol . 2018 Apr; 74(Pt 4):321-331. PMID: 29652259
The crystal structures of native class II fructose-1,6-bisphosphatase (FBPaseII) from Mycobacterium tuberculosis at 2.6 Å resolution and two active-site protein variants are presented. The variants were complexed with the reaction...