Cedric J Laedermann
Overview
Explore the profile of Cedric J Laedermann including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
246
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0
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Recent Articles
1.
Deftu A, Chu Sin Chung P, Laedermann C, Gillet L, Pertin M, Kirschmann G, et al.
eNeuro
. 2022 Feb;
9(2).
PMID: 35131865
The antidiabetic drug metformin has been shown to reduce pain hypersensitivity in preclinical models of chronic pain and in neuropathic pain in humans. Multiple intracellular pathways have been described as...
2.
Laedermann C, Abriel H, Decosterd I
Front Pharmacol
. 2015 Nov;
6:263.
PMID: 26594175
In the peripheral sensory nervous system the neuronal expression of voltage-gated sodium channels (Navs) is very important for the transmission of nociceptive information since they give rise to the upstroke...
3.
Suter M, Bhuiyan Z, Laedermann C, Kuntzer T, Schaller M, Stauffacher M, et al.
Anesthesiology
. 2014 Oct;
122(2):414-23.
PMID: 25285947
Background: Mutations in the SCN9A gene cause chronic pain and pain insensitivity syndromes. We aimed to study clinical, genetic, and electrophysiological features of paroxysmal extreme pain disorder (PEPD) caused by...
4.
Laedermann C, Decosterd I, Abriel H
Handb Exp Pharmacol
. 2014 Apr;
221:231-50.
PMID: 24737239
Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation. The amiloride-sensitive epithelial...
5.
Laedermann C, Pertin M, Suter M, Decosterd I
Mol Pain
. 2014 Mar;
10:19.
PMID: 24618114
Background: Dysregulation of voltage-gated sodium channels (Na(v)s) is believed to play a major role in nerve fiber hyperexcitability associated with neuropathic pain. A complete transcriptional characterization of the different isoforms...
6.
Laedermann C, Syam N, Pertin M, Decosterd I, Abriel H
Front Cell Neurosci
. 2013 Sep;
7:137.
PMID: 24009557
Voltage-gated sodium channels (Navs) are glycoproteins composed of a pore-forming α-subunit and associated β-subunits that regulate Nav α-subunit plasma membrane density and biophysical properties. Glycosylation of the Nav α-subunit also...
7.
Laedermann C, Cachemaille M, Kirschmann G, Pertin M, Gosselin R, Chang I, et al.
J Clin Invest
. 2013 Jun;
123(7):3002-13.
PMID: 23778145
Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized by the dysregulation of voltage-gated sodium channels (Navs) expressed in dorsal root ganglion (DRG) sensory neurons....
8.
Suter M, Kirschmann G, Laedermann C, Abriel H, Decosterd I
Anesthesiology
. 2012 Dec;
118(1):160-72.
PMID: 23221868
Background: Voltage-gated sodium channels dysregulation is important for hyperexcitability leading to pain persistence. Sodium channel blockers currently used to treat neuropathic pain are poorly tolerated. Getting new molecules to clinical...