Cedric Hubeau
Overview
Explore the profile of Cedric Hubeau including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
679
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0
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Recent Articles
1.
Tan Y, Mosallanejad K, Zhang Q, OBrien S, Clements M, Perper S, et al.
Front Immunol
. 2024 Mar;
15:1293883.
PMID: 38455057
Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated...
2.
Abid S, Marcos E, Parpaleix A, Amsellem V, Breau M, Houssaini A, et al.
Eur Respir J
. 2019 Jul;
54(4).
PMID: 31320454
Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH).To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (PASMCs) collaborate to stimulate PASMC growth and whether the...
3.
Primiano M, Lefker B, Bowman M, Bree A, Hubeau C, Bonin P, et al.
J Immunol
. 2016 Aug;
197(6):2421-33.
PMID: 27521339
A critical component of innate immune response to infection and tissue damage is the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome, and this pathway and its activation products...
4.
Benam K, Villenave R, Lucchesi C, Varone A, Hubeau C, Lee H, et al.
Nat Methods
. 2015 Dec;
13(2):151-7.
PMID: 26689262
Here we describe the development of a human lung 'small airway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying microvascular endothelium that experiences fluid flow, which allows for analysis...
5.
Kaila N, Follows B, Leung L, Thomason J, Huang A, Moretto A, et al.
J Med Chem
. 2014 Feb;
57(4):1299-322.
PMID: 24512187
Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of metabolism,...
6.
Hubeau C, Kubera J, Masek-Hammerman K, Williams C
Clin Sci (Lond)
. 2013 Jun;
125(10):483-93.
PMID: 23738811
Increased systemic and pulmonary levels of IL-6 (interleukin-6) are associated with the severity of exacerbations and decline of lung function in patients with COPD (chronic obstructive pulmonary disease). Whether IL-6...
7.
Nance J, Vannella K, Worth D, David C, Carter D, Noor S, et al.
PLoS Pathog
. 2012 Dec;
8(11):e1002990.
PMID: 23209401
Chronic infections represent a continuous battle between the host's immune system and pathogen replication. Many protozoan parasites have evolved a cyst lifecycle stage that provides it with increased protection from...
8.
Kaila N, Huang A, Moretto A, Follows B, Janz K, Lowe M, et al.
J Med Chem
. 2012 Jun;
55(11):5088-109.
PMID: 22651823
New classes of CRTH2 antagonists, the pyridazine linker containing indole acetic acids, are described. The initial hit 1 had good potency but poor permeability, metabolic stability, and PK. Initial optimization...
9.
Williams C, Rahman S, Hubeau C, Ma H
Toxicol Pathol
. 2012 Feb;
40(2):205-15.
PMID: 22301949
Cytokines are critical in allergic intercellular communication networks, and they contribute to disease pathology through the recruitment and activation of pro-inflammatory leukocytes and in chronic disease to pro-fibrotic/remodeling events. Th2...
10.
Fitz L, DeClercq C, Brooks J, Kuang W, Bates B, Demers D, et al.
Am J Respir Cell Mol Biol
. 2011 Aug;
46(1):71-9.
PMID: 21836154
The expression of acidic mammalian chitinase (AMCase) is associated with Th2-driven respiratory disorders. To investigate the potentially pathological role of AMCase in allergic airway disease (AAD), we sensitized and challenged...