Cecilia Saiz
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Explore the profile of Cecilia Saiz including associated specialties, affiliations and a list of published articles.
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17
Citations
110
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Recent Articles
1.
Mojica M, Hausman B, Pearlmutter B, Zink E, Wilson B, Villamil V, et al.
Microbiol Spectr
. 2025 Mar;
:e0234624.
PMID: 40084911
Tebipenem pivoxil has potent activity against pathogens, but requires combination with β-lactamase inhibitor to achieve activity against carbapenemase producers, including metallo-β-lactamases (MBLs). Herein, we evaluate the potential of tebipenem pivoxil,...
2.
Villamil V, Rossi M, Mojica M, Hinchliffe P, Martinez V, Castillo V, et al.
J Med Chem
. 2024 Feb;
67(5):3795-3812.
PMID: 38373290
Antimicrobial resistance is a global public health threat. Metallo-β-lactamases (MBLs) inactivate β-lactam antibiotics, including carbapenems, are disseminating among Gram-negative bacteria, and lack clinically useful inhibitors. The evolving bisthiazolidine (BTZ) scaffold...
3.
Villamil V, Vairoletti F, Tijman A, Lopez G, Peixoto de Abreu Lima A, Saiz C, et al.
ACS Omega
. 2023 Nov;
8(45):42114-42125.
PMID: 38024698
The kinetic resolution of racemic 1,3-thiazolo[3,4-]benzimidazoline (TBIM) heterocycles was achieved using whole cells expressing the MAO-N D11 enzyme. Several cosolvents were screened using TBIM as the substrate. DMF was the...
4.
Villamil V, Saiz C, Mahler G
Front Chem
. 2022 Sep;
10:934376.
PMID: 36072700
The reversibility of the thiol-thioester linkage has been broadly employed in many fields of biochemistry (lipid synthesis) and chemistry (dynamic combinatorial chemistry and material science). When the transthioesterification is followed...
5.
Vairoletti F, Paulino M, Mahler G, Salinas G, Saiz C
Molecules
. 2022 May;
27(9).
PMID: 35566007
A recent screen of 67,012 compounds identified a new family of compounds with excellent nematicidal activity: the -substituted benzamide families Wact-11 and Wact-12. These compounds are active against and parasitic...
6.
Vairoletti F, Baron A, Saiz C, Mahler G, Salinas G
MicroPubl Biol
. 2021 Dec;
2021.
PMID: 34870110
Parasitic nematodes constitute a health problem for humans, livestock and crops, and cause huge economic losses to developing-country economies. Due to the spread of nematicide resistance, there is an urgent...
7.
Villamil V, Saiz C, Mahler G
Tetrahedron
. 2021 Nov;
94.
PMID: 34744193
Classic acetyl thioester protection/deprotection methodologies are widely used in organic synthesis, but deprotection step usually requires harsh conditions not suitable for labile substrates. In this work, a new method for...
8.
Martinez V, Villamil V, Duarte D, Saiz C, Davyt D, Fontana C, et al.
European J Org Chem
. 2021 Sep;
2020(9):1084-1092.
PMID: 34531701
Bisthiazolidines (BTZ) are bicyclic compounds considered penicillin analogs that inhibit the full range of Metallo-β-Lactamases (MBLs) and potentiate β-lactam activity against resistant bacteria. Herein we present a new methodology to...
9.
Vairoletti F, Medeiros A, Fontan P, Melendrez J, Tabarez C, Salinas G, et al.
Medchemcomm
. 2019 Nov;
10(8):1481-1487.
PMID: 31673311
1,4-Thiazepines derivatives are pharmacologically important heterocycles with different applications in medicinal chemistry. In the present work, we describe the preparation of new bicyclic thiazolidinyl-1,4-thiazepines by reaction between azadithiane compounds and...
10.
Saiz C, Villamil V, Gonzalez M, Rossi M, Martinez L, Suescun L, et al.
Tetrahedron Asymmetry
. 2017 Jun;
28(1):110-117.
PMID: 28579699
The synthesis of new oxazolidinylthiazolidines bicycles, oxygen analogues of bisthiazolidines, also known as metallo-β-lactamase inhibitors is described. The reaction of β-aminoalcohols and 2,5-dihydroxy-1,4-dithiane led to oxazolidinylthiazolidines and/or dithia-azabicycles as the...