Cecile Otten
Overview
Explore the profile of Cecile Otten including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
394
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Recent Articles
1.
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Anticevic I, Otten C, et al.
Cell
. 2024 Sep;
187(20):5698-5718.e26.
PMID: 39265577
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of...
2.
Anticevic I, Otten C, Popovic M
Front Cell Dev Biol
. 2024 Sep;
12:1394531.
PMID: 39228401
DNA-protein crosslinks pose a significant challenge to genome stability and cell viability. Efficient repair of DPCs is crucial for preserving genomic integrity and preventing the accumulation of DNA damage. Despite...
3.
Anticevic I, Otten C, Vinkovic L, Jukic L, Popovic M
Open Biol
. 2023 Oct;
13(10):230113.
PMID: 37788708
DNA-protein crosslinks (DPCs) are frequent and damaging DNA lesions that affect all DNA transactions, which in turn can lead to the formation of double-strand breaks, genomic instability and cell death....
4.
Grdseloff N, Boulday G, Rodel C, Otten C, Vannier D, Cardoso C, et al.
Sci Rep
. 2023 Apr;
13(1):5572.
PMID: 37019926
The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells. Mutations of CCM genes within...
5.
Karaica D, Mihaljevic I, Vujica L, Bosnjak A, Dragojevic J, Otten C, et al.
Microsc Res Tech
. 2022 Dec;
86(3):294-310.
PMID: 36453864
The increasing use of the zebrafish model in biomedical and (eco)toxicological studies aimed at understanding the function of various proteins highlight the importance of optimizing existing methods to study gene...
6.
Flinn M, Otten C, Brandt Z, Bostrom J, Kenarsary A, Wan T, et al.
Development
. 2020 Aug;
147(16).
PMID: 32843528
The Hippo-Yap pathway regulates multiple cellular processes in response to mechanical and other stimuli. In , the polarity protein Lethal (2) giant larvae [L(2)gl], negatively regulates Hippo-mediated transcriptional output. However,...
7.
Cardoso C, Arnould M, De Luca C, Otten C, Abdelilah-Seyfried S, Heredia A, et al.
Stroke
. 2020 Jan;
51(4):1272-1278.
PMID: 31992178
Background and Purpose- Cerebral cavernous malformations (CCMs) are vascular malformations of the brain that lead to cerebral hemorrhages. A pharmacological treatment is needed especially for patients with nonoperable deep-seated lesions....
8.
Rodel C, Otten C, Donat S, Lourenco M, Fischer D, Kuropka B, et al.
Circ Res
. 2019 Sep;
125(10):e43-e54.
PMID: 31495257
Rationale: Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. Why...
9.
Otten C, Knox J, Boulday G, Eymery M, Haniszewski M, Neuenschwander M, et al.
EMBO Mol Med
. 2018 Sep;
10(10).
PMID: 30181117
Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in...
10.
Donat S, Lourenco M, Paolini A, Otten C, Renz M, Abdelilah-Seyfried S
Elife
. 2018 Jan;
7.
PMID: 29364115
Endothelial cells respond to different levels of fluid shear stress through adaptations of their mechanosensitivity. Currently, we lack a good understanding of how this contributes to sculpting of the cardiovascular...