Catherine C Hedrick
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Explore the profile of Catherine C Hedrick including associated specialties, affiliations and a list of published articles.
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120
Citations
9378
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Recent Articles
11.
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy
Kaczanowska S, Murty T, Alimadadi A, Contreras C, Duault C, Subrahmanyam P, et al.
Cancer Cell
. 2023 Dec;
42(1):35-51.e8.
PMID: 38134936
Chimeric antigen receptor T cells (CAR-Ts) have remarkable efficacy in liquid tumors, but limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 CAR-Ts (GD2-CAR.OX40.28.z.iC9), demonstrating...
12.
Meyer M, Dinh H, Alimadadi A, Araujo D, Chatterjee N, Gutierrez N, et al.
Front Immunol
. 2023 Nov;
14:1224045.
PMID: 38022639
Purpose: Due to their abundance in the blood, low RNA content, and short lifespan, neutrophils have been classically considered to be one homogenous pool. However, recent work has found that...
13.
Iqneibi S, Saigusa R, Khan A, Oliaeimotlagh M, Suthahar S, Kumar S, et al.
Front Immunol
. 2023 Oct;
14:1239148.
PMID: 37828989
Coronary artery disease (CAD) is a major cause of death worldwide. The role of CD8+ T cells in CAD is unknown. Recent studies suggest a breakdown of tolerance in atherosclerosis,...
14.
Padgett L, Marcovecchio P, Olingy C, Araujo D, Steel K, Dinh H, et al.
Front Immunol
. 2023 Jul;
14:1101497.
PMID: 37426658
CD8 T cells drive anti-cancer immunity in response to antigen-presenting cells such as dendritic cells and subpopulations of monocytes and macrophages. While CD14 classical monocytes modulate CD8 T cell responses,...
15.
Hillman H, Khan N, Singhania A, Dubelko P, Soldevila F, Tippalagama R, et al.
Front Immunol
. 2023 Jan;
13:1087010.
PMID: 36713384
Introduction: Previous studies suggest that monocytes are an important contributor to tuberculosis (TB)-specific immune signatures in blood. Methods: Here, we carried out comprehensive single-cell profiling of monocytes in paired blood...
16.
Vallejo J, Saigusa R, Gulati R, Suthahar S, Suryawanshi V, Alimadadi A, et al.
BMC Biol
. 2022 Oct;
20(1):237.
PMID: 36266696
No abstract available.
17.
Johnson J, Meneses-Salas E, Ramadass M, Monfregola J, Rahman F, Carvalho Gontijo R, et al.
Nat Commun
. 2022 Sep;
13(1):5529.
PMID: 36130971
Dysregulated secretion in neutrophil leukocytes associates with human inflammatory disease. The exocytosis response to triggering stimuli is sequential; gelatinase granules modulate the initiation of the innate immune response, followed by...
18.
Saigusa R, Vallejo J, Gulati R, Suthahar S, Suryawanshi V, Alimadadi A, et al.
Int J Mol Sci
. 2022 Sep;
23(17).
PMID: 36077273
Despite the decades-old knowledge that males and people with diabetes mellitus (DM) are at increased risk for coronary artery disease (CAD), the reasons for this association are only partially understood....
19.
Vallejo J, Saigusa R, Gulati R, Suthahar S, Suryawanshi V, Alimadadi A, et al.
BMC Biol
. 2022 Aug;
20(1):193.
PMID: 36045343
Background: Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in clinical studies. Here, we developed combined protein (40 antibodies) and transcript single-cell (sc)RNA...
20.
Saigusa R, Roy P, Freuchet A, Gulati R, Ghosheh Y, Suthahar S, et al.
Nat Cardiovasc Res
. 2022 Aug;
1(5):462-475.
PMID: 35990517
Atherosclerosis is accompanied by a CD4 T cell response to apolipoprotein B (APOB). Major Histocompatibility Complex (MHC)-II tetramers can be used to isolate antigen-specific CD4 T cells by flow sorting....