Cassandra R Zylstra
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Explore the profile of Cassandra R Zylstra including associated specialties, affiliations and a list of published articles.
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11
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Recent Articles
1.
Cui Y, Niziolek P, MacDonald B, Zylstra C, Alenina N, Robinson D, et al.
Nat Med
. 2011 May;
17(6):684-91.
PMID: 21602802
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5...
2.
Lindvall C, Zylstra C, Evans N, West R, Dykema K, Furge K, et al.
PLoS One
. 2009 Jun;
4(6):e5813.
PMID: 19503830
Canonical Wnt signals are transduced through a Frizzled receptor and either the LRP5 or LRP6 co-receptor; such signals play central roles during development and in disease. We have previously shown...
3.
Robinson D, Zylstra C, Williams B
Curr Drug Targets
. 2008 Aug;
9(7):571-80.
PMID: 18673243
Canonical Wnt signaling has emerged as an important pathway that underlies the initia nottion of prostate cancer. Both human cancers and mouse models have confirmed that mutations or altered expression...
4.
Bruxvoort K, Charbonneau H, Giambernardi T, Goolsby J, Qian C, Zylstra C, et al.
Cancer Res
. 2007 Mar;
67(6):2490-6.
PMID: 17363566
Alterations of the Wnt/beta-catenin signaling pathway are positively associated with the development and progression of human cancer, including carcinoma of the prostate. To determine the role of activated Wnt/beta-catenin signaling...
5.
Liu X, Bruxvoort K, Zylstra C, Liu J, Cichowski R, Faugere M, et al.
Proc Natl Acad Sci U S A
. 2007 Feb;
104(7):2259-64.
PMID: 17287359
Bone formation is carried out by the osteoblast, a mesenchymal cell whose lifespan and activity are regulated by growth factor signaling networks. Growth factors activate phosphatidylinositol 3-kinase (PI3K), which enhances...
6.
Lindvall C, Evans N, Zylstra C, Li Y, Alexander C, Williams B
J Biol Chem
. 2006 Sep;
281(46):35081-7.
PMID: 16973609
Canonical Wnt signaling has emerged as a critical regulatory pathway for stem cells. The association between ectopic activation of Wnt signaling and many different types of human cancer suggests that...
7.
Holmen S, Zylstra C, Mukherjee A, Sigler R, Faugere M, Bouxsein M, et al.
J Biol Chem
. 2005 Apr;
280(22):21162-8.
PMID: 15802266
Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt...
8.
Robertson S, Schoumans J, Looyenga B, Yuhas J, Zylstra C, Koeman J, et al.
Int J Oncol
. 2005 Feb;
26(3):629-34.
PMID: 15703817
The Ink4a/Arf locus is functionally linked to the Rb and p53 pathways through the action of its two gene products. Mouse models null for this locus show rapid onset of...
9.
Holmen S, Robertson S, Zylstra C, Williams B
Biochem Biophys Res Commun
. 2005 Feb;
328(2):533-9.
PMID: 15694380
An XWnt8-Fz5 fusion protein synergizes with LRP6 to potently activate beta-catenin-dependent signaling. Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it...
10.
Holmen S, Giambernardi T, Zylstra C, Buckner-Berghuis B, Resau J, Hess J, et al.
J Bone Miner Res
. 2004 Nov;
19(12):2033-40.
PMID: 15537447
Unlabelled: Humans and mice lacking Lrp5 have low BMD. To evaluate whether Lrp5 and Lrp6 interact genetically to control bone or skeletal development, we created mice carrying mutations in both...