Cassandra R Harapas
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Explore the profile of Cassandra R Harapas including associated specialties, affiliations and a list of published articles.
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14
Citations
804
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Recent Articles
1.
Moecking J, Laohamonthonkul P, Mese K, Hagelueken G, Steiner A, Harapas C, et al.
J Biol Chem
. 2022 Oct;
298(12):102645.
PMID: 36309085
The inflammasome sensor NLRP1 (nucleotide-binding oligomerization domain-like receptor containing a pyrin domain 1) detects a variety of pathogen-derived molecular patterns to induce an inflammatory immune response by triggering pyroptosis and...
2.
Harapas C, Robinson K, Lay K, Wong J, Moreno Traspas R, Nabavizadeh N, et al.
Sci Immunol
. 2022 Sep;
7(75):eabi4611.
PMID: 36112693
Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo is not yet established. Here, we report three families with immune-associated defects,...
3.
Robinson K, Toh G, Rozario P, Chua R, Bauernfried S, Sun Z, et al.
Science
. 2022 Jul;
377(6603):328-335.
PMID: 35857590
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. Here, we report that human NLRP1 senses the...
4.
Steiner A, Hrovat-Schaale K, Prigione I, Yu C, Laohamonthonkul P, Harapas C, et al.
Nat Commun
. 2022 Apr;
13(1):2321.
PMID: 35484149
Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha causes COPA syndrome and is associated with...
5.
Harapas C, Idiiatullina E, Al-Azab M, Hrovat-Schaale K, Reygaerts T, Steiner A, et al.
Nat Rev Immunol
. 2022 Feb;
22(9):535-549.
PMID: 35197578
A cell is delimited by numerous borders that define specific organelles. The walls of some organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but some are more...
6.
Davidson S, Yu C, Steiner A, Ebstein F, Baker P, Jarur-Chamy V, et al.
Sci Immunol
. 2022 Feb;
7(68):eabi6763.
PMID: 35148201
Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified...
7.
Moecking J, Laohamonthonkul P, Chalker K, White M, Harapas C, Yu C, et al.
J Allergy Clin Immunol
. 2020 Dec;
147(6):2134-2145.e20.
PMID: 33378691
Background: NLRP1 is an innate immune sensor that can form cytoplasmic inflammasome complexes. Polymorphisms in NLRP1 are linked to asthma; however, there is currently no functional or mechanistic explanation for...
8.
Yu C, Davidson S, Harapas C, Hilton J, Mlodzianoski M, Laohamonthonkul P, et al.
Cell
. 2020 Oct;
183(3):636-649.e18.
PMID: 33031745
Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB)...
9.
Zhong F, Robinson K, Teo D, Tan K, Lim C, Harapas C, et al.
J Biol Chem
. 2018 Oct;
293(49):18864-18878.
PMID: 30291141
The inflammasome is a critical molecular complex that activates interleukin-1 driven inflammation in response to pathogen- and danger-associated signals. Germline mutations in the inflammasome sensor NLRP1 cause Mendelian systemic autoimmunity...
10.
Tye H, Yu C, Simms L, de Zoete M, Kim M, Zakrzewski M, et al.
Nat Commun
. 2018 Sep;
9(1):3728.
PMID: 30214011
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse...