Cassandra Buhl
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Explore the profile of Cassandra Buhl including associated specialties, affiliations and a list of published articles.
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9
Citations
57
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Recent Articles
1.
Riel A, Rungelrath V, Elwaie T, Rasheed O, Hicks L, Ettenger G, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337517
The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, and therefore represents a promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with...
2.
Jackson K, Buhl C, Miller S, Khalaf J, Ward J, Sands C, et al.
Front Immunol
. 2024 Aug;
15:1421758.
PMID: 39108263
Introduction: Atopic diseases have been steadily increasing over the past decades and effective disease-modifying treatment options are urgently needed. These studies introduce a novel synthetic Toll-like receptor 4 (TLR4) agonist,...
3.
Abdelwahab W, Le-Vinh B, Riffey A, Hicks L, Buhl C, Ettenger G, et al.
ACS Appl Bio Mater
. 2024 Jun;
7(6):3877-3889.
PMID: 38832760
Adjuvants and immunomodulators that effectively drive a Th17-skewed immune response are not part of the standard vaccine toolkit. Vaccine adjuvants and delivery technologies that can induce Th17 or Th1/17 immunity...
4.
Rasheed O, Buhl C, Evans J, Holley D, Ryter K
Tetrahedron
. 2023 Mar;
132.
PMID: 36874612
The identification of Mincle as the C-type lectin receptor on innate immune cells responsible for binding TDM and the realization that this receptor could be key to productive vaccines for...
5.
Rasheed O, Buhl C, Evans J, Ryter K
ChemMedChem
. 2021 Jun;
17(10):e202100376.
PMID: 34128340
No abstract available.
6.
Rasheed O, Buhl C, Evans J, Ryter K
ChemMedChem
. 2021 Jan;
16(8):1246-1251.
PMID: 33415819
Mincle agonists have been shown to induce inflammatory cytokine production, such as tumor necrosis factor-alpha (TNF) and promote the development of a Th1/Th17 immune response that might be crucial to...
7.
Rasheed O, Ettenger G, Buhl C, Child R, Miller S, Evans J, et al.
Bioorg Med Chem
. 2020 Jul;
28(14):115564.
PMID: 32616186
6,6'-Aryl trehalose derivatives have been synthesized with a view towards identifying novel Th-17-inducing vaccine adjuvants based on the high affinity Mincle ligand Brartemicin. The initial structure-activity relationships of these novel...
8.
Ryter K, Ettenger G, Rasheed O, Buhl C, Child R, Miller S, et al.
J Med Chem
. 2019 Dec;
63(1):309-320.
PMID: 31809053
() continues to be a major health threat worldwide, and the development of vaccines could play a pivotal role in the prevention and control of this devastating epidemic. Th17-mediated immunity...
9.
Smith A, Miller S, Buhl C, Child R, Whitacre M, Schoener R, et al.
Front Immunol
. 2019 Mar;
10:338.
PMID: 30873180
Despite the ever present need for an effective () vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against are not wholly defined, but Th1 and likely...