Carolina M Pusec
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Explore the profile of Carolina M Pusec including associated specialties, affiliations and a list of published articles.
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9
Citations
162
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Recent Articles
1.
Pusec C, Ilievski V, De Jesus A, Farooq Z, Zapater J, Sweis N, et al.
Sci Rep
. 2023 May;
13(1):8034.
PMID: 37198225
A primary role of the liver is to regulate whole body glucose homeostasis. Glucokinase (GCK) is the main hexokinase (HK) expressed in hepatocytes and functions to phosphorylate the glucose that...
2.
Pusec C, Wolsky R, Llerena C, Sura P
Cureus
. 2022 Nov;
14(10):e30433.
PMID: 36407193
Acute hepatitis is an uncommon sequela of herbal supplement use. Regardless, considering the hepatotoxic effects of natural supplements is important, especially in patients taking other medications or substances. We herein...
3.
De Jesus A, Pusec C, Nguyen T, Keyhani-Nejad F, Gao P, Weinberg S, et al.
STAR Protoc
. 2022 Sep;
3(4):101668.
PMID: 36103306
Peritoneal macrophages (PMs) have been shown to have higher stability compared to other macrophage subtypes. However, obtaining enough PMs from a single mouse is often a limitation for metabolomics analysis....
4.
De Jesus A, Keyhani-Nejad F, Pusec C, Goodman L, Geier J, Stoolman J, et al.
Mol Cell
. 2022 Mar;
82(7):1261-1277.e9.
PMID: 35305311
The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative metabolic routes, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1...
5.
Zapater J, Lednovich K, Khan M, Pusec C, Layden B
Trends Endocrinol Metab
. 2021 Nov;
33(1):72-84.
PMID: 34782236
Glucose phosphorylation by hexokinases (HKs) traps glucose in cells and facilitates its usage in metabolic processes dependent on cellular needs. HK domain-containing protein-1 (HKDC1) is a recently discovered protein with...
6.
Lee S, Pusec C, Norris G, De Jesus A, Diaz-Ruiz A, Muratalla J, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Jan;
11(5):1291-1311.
PMID: 33444819
Background & Aims: Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity...
7.
Pusec C, De Jesus A, Khan M, Terry A, Ludvik A, Xu K, et al.
Endocrinology
. 2018 Dec;
160(2):313-330.
PMID: 30517626
Glucokinase (GCK) is the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. Recently, we proposed HK domain-containing 1 (HKDC1) to...
8.
Ludvik A, Pusec C, Priyadarshini M, Angueira A, Guo C, Lo A, et al.
Endocrinology
. 2016 Jul;
157(9):3452-61.
PMID: 27459389
In a recent genome-wide association study, hexokinase domain-containing protein 1, or HKDC1, was found to be associated with gestational glucose levels during 2-hour glucose tolerance tests at 28 weeks of...
9.
Jarrett C, Lekic M, Smith C, Pusec C, Sweazea K
J Comp Physiol B
. 2013 May;
183(7):959-67.
PMID: 23640140
For mammals, acetylcholine (ACh) promotes endothelium-dependent vasodilation primarily through nitric oxide (NO) and prostaglandin-mediated pathways, with varying reliance on endothelial-derived hyperpolarizing factors. Currently, no studies have been conducted on small...